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Golgicide A

SIGMA/G0923 - ≥98% (HPLC)

Synonym: 6,8-Difluoro-4-pyridin-3-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline; CID 25113626; GCA

CAS Number: 1005036-73-6
Empirical Formula (Hill Notation): C17H14F2N2
Molecular Weight: 284.30
MDL Number: MFCD27937048
Linear Formula: C17H14F2N2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-G0923-5MG 5 mg
 $205.00
1/EA		 Add To Favorites
45-G0923-25MG 25 mg
 $749.00
1/EA		 Add To Favorites
This picture is provided solely for illustration purposes, it may have been created or edited with AI. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.
This image depicts G0923-25MG.

 

assay ≥98% (HPLC)
form solid
InChI 1S/C17H14F2N2/c18-11-7-14-12-4-1-5-13(12)16(10-3-2-6-20-9-10)21-17(14)15(19)8-11/h1-4,6-9,12-13,16,21H,5H2/t12-,13+,16?/m0/s1
InChI key NJZHEQOUHLZCOX-FTLRAWMYSA-N
Quality Level 100 
SMILES string Fc1cc(F)c2NC([C@@H]3CC=C[C@@H]3c2c1)c4cccnc4
solubility DMSO: >10 mg/mL
storage temp. room temp
Application: Golgicide A has been used as an inhibitor in retrotransposition assays and as an inhibitor of Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 protein (GBF1) in HeLa cells.
Biochem/physiol Actions: Golgicide A is a potent, highly specific, reversible inhibitor of the cis-Golgi ArfGEF GBF1.
Biochem/physiol Actions: Golgicide A is a potent, highly specific, reversible inhibitor of the cis-Golgi ArfGEF GBF1. Arf proteins are members of the Ras superfamily of small guanosine triphosphatases (GTPases) that mediate vesicular transport. Golgicide A binds within an interfacial cleft formed between Arf1 and the GBF1 Sec7 domain. Golgicide A is a unique and powerful tool for further elucidating the mechanisms underlying assembly and transport within the Golgi, comparable to the use of dynasore for studying the dynamics of dynamin-mediated clathrin coat formation.
Features and Benefits: This compound is a featured product for Cyclic Nucleotide research. Click here  to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Packaging: 5, 25 mg in glass bottle
Symbol GHS07  GHS07
Signal word Warning
Hazard statements H319
Precautionary statements P305 + P351 + P338
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. room temp
UNSPSC 12352200

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