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GSK4112

SIGMA/G0673 - ≥98% (HPLC)

Synonym: 1,1-Dimethylethyl N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate; SR6452

CAS Number: 1216744-19-2
Empirical Formula (Hill Notation): C18H21ClN2O4S
Molecular Weight: 396.89
MDL Number: MFCD12912412
Linear Formula: C18H21ClN2O4S
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-G0673-5MG 5 mg
 $167.00
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45-G0673-25MG 25 mg
 $482.00
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assay ≥98% (HPLC)
color off-white to tan
form powder
InChI 1S/C18H21ClN2O4S/c1-18(2,3)25-17(22)12-20(10-13-4-6-14(19)7-5-13)11-15-8-9-16(26-15)21(23)24/h4-9H,10-12H2,1-3H3
InChI key WYSLOKHVFKLWOU-UHFFFAOYSA-N
originator GlaxoSmithKline
Quality Level 100 
SMILES string CC(C)(C)OC(=O)CN(Cc1ccc(Cl)cc1)Cc2ccc(s2)[N+]([O-])=O
solubility DMSO: >20 mg/mL
storage temp. 2-8°C
Biochem/physiol Actions: GSK4112 is a rev-erbα, (orphan nuclear receptor NR1D1) agonist, the first agent able to reset the circadian clock in a phase-dependent manner. Rev-erbα impacts the precision of the circadian clock by repressing target gene activities with the help of a nuclear receptor co-repressor complex (NCoR) and HDAC3. GSK4112 competes with heme (rev-erb′s natural ligand) and enhances co-repressor complex recruitment and thus, repression of transcription. suggests that pharmacological modulation through Rev-erb may provide new routes to treat metabolic diseases, especially disorders of adipogenesis regulated by rev-erba.
Biochem/physiol Actions: GSK4112 is s reverb (REV-ERBα, orphan nuclear receptor NR1D1) agonist; resets circadian clock.
Features and Benefits: This compound is a featured product for Gene Regulation research. Click here  to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits: This compound was developed by GlaxoSmithKline . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Packaging: 5, 25 mg in glass bottle
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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