R(+)-Baclofen hydrochloride
SIGMA/G013 - solid
Synonym: Arbaclofen hydrochloride; R(+)-β-(Aminomethyl)-4-chlorobenzenepropanoic acid hydrochloride; STX209
CAS Number: 63701-55-3
Empirical Formula (Hill Notation): C10H12ClNO2 · HCl
Molecular Weight: 250.12
MDL Number: MFCD00078579
Linear Formula: C10H12ClNO2 · HCl
Product Type: Chemical
| color | white |
| form | solid |
| InChI | 1S/C10H12ClNO2.ClH/c11-9- |
| InChI key | WMNUVYYLMCMHLU-QRPNPIFTSA |
| optical activity | [α]28/D +3.8°, c = 0.9 in methanol(lit.) |
| Quality Level | 100  |
| SMILES string | Cl[H].NC[C@H](CC(O)=O)c1c |
| solubility | DMSO: >20 mg/mL |
| H2O: 26 mg/mL (Solutions may be stored for several weeks at 4 °C.) | |
| storage condition | desiccated |
| Application: | R(+)-Baclofen hydrochloride has been used as a GABAB receptor agonist to study its effects on M43068-induced antinociception in rat models. It has also been used as a GABAB receptor agonist to study its effects on amphetamine-induced behavior and neurochemical responses in rat striatum. |
| Biochem/physiol Actions: | Baclofen is a derivative of γ-aminobutyric acid (GABA) and acts as a 4-aminobutanoic acid receptor (GABAB) agonist. It interacts stereospecifically with the GABA receptor and exhibits antispastic effects.Baclofen shows therapeutic effects against paroxysmal pain of trigeminal neuralgia and spinal spasticity. R(+)-Baclofen is a more active enantiomer. |
| Other Notes: | Same enantiomer as R(−)-baclofen free base. |
| Packaging: | 25, 100, 500 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| UNSPSC | 12352200 |