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Fluticasone propionate

SIGMA/F9428 - ≥98% (HPLC), powder

Synonym: (6α,11β,16α,17α)-6,9-Difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)androsta-1,4-diene-17-carbothioic acid S-(fluoromethyl) ester

CAS Number: 80474-14-2
Empirical Formula (Hill Notation): C25H31F3O5S
Molecular Weight: 500.57
MDL Number: MFCD00866007
Linear Formula: C25H31F3O5S
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-F9428-5MG 5 mg
 $125.00
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assay ≥98% (HPLC)
color white
form powder
InChI 1S/C25H31F3O5S/c1-5-20(31)33-25(21(32)34-12-26)13(2)8-15-16-10-18(27)17-9-14(29)6-7-22(17,3)24(16,28)19(30)11-23(15,25)4/h6-7,9,13,15-16,18-19,30H,5,8,10-12H2,1-4H3/t13-,15+,16+,18+,19+,22+,23+,24+,25+/m1/s1
InChI key WMWTYOKRWGGJOA-CENSZEJFSA-N
originator GlaxoSmithKline
Quality Level 100 
SMILES string CCC(=O)O[C@@]1([C@H](C)C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]12C)C(=O)SCF
solubility DMSO: ≥10 mg/mL
Biochem/physiol Actions: Fluticasone propionate is a second generation glucocorticoid. Used as an anti-inflammatory agent for asthma. Shown to enhance eosinophil apoptosis in a concentration-dependent manner via the glucocorticoid receptor.
Features and Benefits: This compound is a featured product for Gene Regulation research. Click here  to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits: This compound was developed by GlaxoSmithKline . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
General description: Fluticasone blocks mast cells, eosinophils, lymphocytes, neutrophils and macrophages.
Packaging: 5 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 2
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
UNSPSC 12352200

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