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FK866 hydrochloride hydrate

SIGMA/F8557 - ≥98% (HPLC)

Synonym: FK866 hydrochloride hydrate; (E)-N-[4-(1-benzoylpiperidin-4-yl)butyl]-3-(pyridin-3-yl)acrylamide; K22.175

CAS Number: 658084-64-1 (free base)
Empirical Formula (Hill Notation): C24H29N3O2·HCl · xH2O
Molecular Weight: 427.97 (anhydrous basis)
MDL Number: MFCD10565943
Linear Formula: C24H29N3O2·HCl · xH2O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-F8557-5MG 5 mg
 $170.00
1/EA		 Add To Favorites
45-F8557-25MG 25 mg
 $676.00
1/EA		 Add To Favorites
This image is provided for informative purposes only and does not represent an actual product label. It should not be used as a substitute for official product labeling.

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C24H29N3O2/c28-23(12-11-21-8-6-15-25-19-21)26-16-5-4-7-20-13-17-27(18-14-20)24(29)22-9-2-1-3-10-22/h1-3,6,8-12,15,19-20H,4-5,7,13-14,16-18H2,(H,26,28)/b12-11+
InChI key KPBNHDGDUADAGP-VAWYXSNFSA-N
Quality Level 100 
SMILES string N2(CCC(CC2)CCCCNC(=O)C=Cc3cnccc3)C(=O)c1ccccc1
solubility DMSO: 10 mg/mL, clear
storage condition desiccated
storage temp. −20°C
Application: FK866 hydrochloride hydrate has been used:
• to investigate its effects on intra-axonal NAD+ levels
• to induce NAD+ depletion
• to reduce the level of tumor necrosis factor-α (TNF-α), nicotinamide phosphoribosyltransferase (NAMPT) and interleukin-6 (IL-6) in the ischemic brain tissue
Biochem/physiol Actions: FK866 is a potent inhibitor of NAD biosynthesis, and a specific inhibitor of NAMPT (Nicotinamide Phosphoribosyltransferase, visfatin, PBEF). NAMPT functions as an intra-cellular and extra-cellular NAD biosynthetic enzyme that is important for regulating metabolism and stress resistance through sirtuins and other NAD-consuming regulators. NAMPT also acts as a cytokine independent of its enzymatic activity, playing a major part in regulating immune responses.
Biochem/physiol Actions: FK866 is a potent inhibitor of NAD biosynthesis.
General description: FK866 is used to treat inflammatory diseases and cancer.
Packaging: 5, 25 mg in glass bottle
Symbol GHS07  GHS07
Signal word Warning
Hazard statements H302
Hazard Codes Xn
Risk Statements 22
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 51111800

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