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Flunarizine dihydrochloride

SIGMA/F8257 - ≥98% (TLC)

Synonym: 1-[Bis(4-fluorophenyl)methyl]-4-(3-phenyl-2-propenyl)piperazine dihydrochloride

CAS Number: 30484-77-6
Empirical Formula (Hill Notation): C26H26F2N2 · 2HCl
Molecular Weight: 477.42
EC Number: 250-216-6
MDL Number: MFCD00058198
Linear Formula: C26H26F2N2 · 2HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-F8257-1G 1 g
 $85.80
1/EA		 Add To Favorites
45-F8257-10G 10 g
 $482.00
1/EA		 Add To Favorites
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: F8257-1G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: F8257-10G

 

assay ≥98% (TLC)
InChI 1S/C26H26F2N2.2ClH/c27-24-12-8-22(9-13-24)26(23-10-14-25(28)15-11-23)30-19-17-29(18-20-30)16-4-7-21-5-2-1-3-6-21;;/h1-15,26H,16-20H2;2*1H/b7-4+;;
InChI key RXKMOPXNWTYEHI-RDRKJGRWSA-N
originator Johnson & Johnson
Quality Level 200 
SMILES string Cl[H].Cl[H].Fc1ccc(cc1)C(N2CCN(CC2)CC=Cc3ccccc3)c4ccc(F)cc4
storage temp. 2-8°C
Application: Flunarizine dihydrochloride has been used to study the effect of flunarizine on epileptiform activity. It is also used to study its effect on high-potassium induced increase of intracellular free calcium.
Biochem/physiol Actions: Blocks T-type Ca2+/Na+ channels.
Biochem/physiol Actions: Blocks T-type Ca2+/Na+ channels; inhibits K+-induced catecholamine release from chromaffin cells
Features and Benefits: This compound was developed by Johnson & Johnson . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
General description: Flunarizine has antihistamine, anticonvulsant and vestibular depressive properties. It protects endothelial cells from calcium overload-induced damage. Flunarizine is used to treat epilepsy, migraine prophylaxis, cerebral blood flow disturbances, peripheral vascular disease and vertigo.
Packaging: 1, 10 g in poly bottle
Symbol GHS07  GHS07
Signal word Warning
Hazard statements H302
Precautionary statements P264 - P270 - P301 + P312 - P501
Hazard Codes Xn
Risk Statements 22
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (TLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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