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Famciclovir

SIGMA/F7932 - ≥98% (HPLC)

Synonym: 2-(2-(2-Amino-9H-purin-9-yl)ethyl)-1,3-propanediol diacetate ester; BRL 42810

CAS Number: 104227-87-4
Empirical Formula (Hill Notation): C14H19N5O4
Molecular Weight: 321.33
MDL Number: MFCD00866964
Linear Formula: C14H19N5O4
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-F7932-10MG 10 mg
 $100.00
1/EA		 Add To Favorites
45-F7932-50MG 50 mg
 $386.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
form solid
InChI 1S/C14H19N5O4/c1-9(20)22-6-11(7-23-10(2)21)3-4-19-8-17-12-5-16-14(15)18-13(12)19/h5,8,11H,3-4,6-7H2,1-2H3,(H2,15,16,18)
InChI key GGXKWVWZWMLJEH-UHFFFAOYSA-N
originator Novartis
Quality Level 100 
SMILES string CC(=O)OCC(CCn1cnc2cnc(N)nc12)COC(C)=O
solubility DMSO: ≥10 mg/mL
storage condition desiccated
storage temp. 2-8°C
Application: Famciclovir is used in herpes virus infections and hepatitis B drug development research. It may be used as a reference compound. Famciclovir may be used to study the factors that control its conversion into penciclovir and other metabolites.
Biochem/physiol Actions: Famciclovir is an antiretroviral guanosine analog used to treat herpesvirus infections and hepatitis B. Famciclovir is rapidly converted to penciclovir. Viral thymidine kinase phosphorylates penciclovir to a monophosphate form that celular kinases convert in turn to penciclovir triphosphate. Penciclovir triphosphate competitively inhibits viral DNA polymerase and thus viral replication. Prolonged administration can lead to resistance; it is often manifested as selection of pre-existing resistant strains with mutations in the reverse transcriptase domain of the DNA polymerase gene.
Biochem/physiol Actions: Famciclovir is an Antiviral; Guanine analog used to treat herpesvirus infections.
Features and Benefits: This compound was developed by Novartis . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Packaging: 10, 50 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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