FGFR3 (397-end), active, GST tagged human
SIGMA/F7930 - PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
Synonym: Eph receptor tyrosine kinase; Eph receptor tyrosine kinase; growth hormone receptor; growth hormone receptor; ACH; CD333; CEK2; HSFGFR3EX; JTK4
Product Type: Chemical
| assay | ≥70% (SDS-PAGE) |
| biological source | human |
| form | buffered aqueous glycerol solution |
| mol wt | ~73 kDa |
| packaging | pkg of 10 μg |
| product line | PRECISIO® Kinase |
| Protein ID accession no. | NM 000142   |
| Quality Level | 200 |
| recombinant | expressed in baculovirus infected Sf9 cells |
| shipped in | dry ice |
| solubility | water: soluble |
| specific activity | 95-129 nmol/min·mg |
| storage temp. | −70°C |
| technique(s) | cell based assay: suitable |
| UniProt accession no. | P22607 |
| Biochem/physiol Actions: | FGFR3 (fibroblast growth factor receptor 3) plays an essential role in the signaling pathways during embryogenesis and angiogenesis. This gene is either mutated or up-regulated in multiple myeloma, cervical carcinoma and nonmuscle-invasive urothelial carcinoma (UC) of the bladder.Apart from this, certain mutations in FGFR3 are also known to be linked with skeletal disorders such as various forms of dwarfism. FGFR3 also plays hepatoprotective function during liver damage. |
| General description: | Research area: Cancer FGFR3 (fibroblast growth factor receptor 3) is a receptor tyrosine kinase (RTK) and belongs to the FGFR subfamily. This subfamily includes four members namely, FGFR1, FGFR2, FGFR3, and FGFR4. It contains a ligand-binding region in its exoplasmic domain, a single transmembrane region, and a tyrosine kinase domain in its intracellular domain.FGFR3 has a strong affinity for canonical FGF ligands. |
| Legal Information: | PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany |
| Physical form: | Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥70% (SDS-PAGE) |
| activity | specific activity: 95-129 nmol/min·mg |
| Storage Temp. | −70°C |
| UNSPSC | 51111800 |