D-Fructose 1,6-bisphosphate trisodium salt hydrate

SIGMA/F6803 - ≥98% (TLC)

Synonym: D(+)Fructofuranose 1,6-diphosphate trisodium salt hydrate; Harden-Young ester; Hexose diphosphate trisodium salt hydrate

CAS Number: 38099-82-0 (anhydrous)
Empirical Formula (Hill Notation): C₆H₁₁Na₃O₁₂P₂ · xH₂O
Molecular Weight: 406.06 (anhydrous basis)
MDL Number: MFCD03427650
Linear Formula: C₆H₁₁Na₃O₁₂P₂ · xH₂O
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-F6803-10MG	10 mg	$34.60 1/EA	Add To Favorites
45-F6803-1G	1 g	$101.00 1/EA	Add To Favorites
45-F6803-5G	5 g	$353.00 1/EA	Add To Favorites

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This image depicts SKU: F6803-1G

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (TLC)
biological source	microbial
cation traces	Na: 14.6-18.8% (dry basis)
color	white to off-white
form	powder
InChI	1S/C6H14O12P2.3Na.H2O/c7-3(1-17-19(11,12)13)5(9)6(10)4(8)2-18-20(14,15)16;;;;/h3,5-7,9-10H,1-2H2,(H2,11,12,13)(H2,14,15,16);;;;1H2/q;3*+1;/p-3/t3-,5-,6-;;;;/m1..../s1
InChI key	ISLNIFDAODOXHN-GNWSQLALSA-K
Quality Level	200
SMILES string	O.[Na+].[Na+].[Na+].O[C@H](COP([O-])([O-])=O)[C@@H](O)[C@H](O)C(=O)COP(O)([O-])=O
solubility	water: 50 mg/mL, clear, colorless to faintly yellow
storage temp.	−20°C
technique(s)	thin layer chromatography (TLC): suitable

Application:	D-Fructose-1,6-bisphosphate (FBP), a common metabolic sugar, is the precursor of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate in the glycolytic pathway. It may be used as an allosteric activator of enzymes such as pyruvate kinase and NAD⁺-dependent L-(+)-lactate dehydrogenase, as an inhibitor of acetate kinase and as a substrate to identify and characterize enzymes such as fructose-1,6-bisphosphate aldolase(s) and fructose-1,6-bisphosphatase(s). FBP is studied as a neuroprotective agent in brain injury.
Biochem/physiol Actions:	Fructose-1,6-biphosphate (F1,6P) is a glycolytic intermediate produced by the transfer of a phosphate from ATP to fructose-6-phosphate by the enzyme phosphofructokinase. Fructose-1,6-biphosphate, along with fructose-2,6-biphosphate, modulates the activity of phosphofructokinase-1 (PFK-1), the rate-limiting step in glycolysis. During glycolysis, aldolase splits Fructose-1,6-biphosphate into dihydroxacetone phosphate (DHAP) and glyceraldehyde phosphate. Fructose-1,6-biphosphate is also an allosteric activator of the M2 isoform of Pyruvate Kinase (PK-M2), the predominant form of pyruvate kinase in cancer cells.
Biochem/physiol Actions:	Fructose-1,6-biphosphate (F1,6P) is a glycolytic intermediate produced by the transfer of a phosphate from ATP to fructose-6-phosphate by the enzyme phosphofructokinase. Fructose-1,6-biphosphate, along with fructose-2,6-biphosphate, modulates the activity of phosphofructokinase-1 (PFK-1), the rate-limiting step in glycolysis. Fructose-1,6-biphosphate is also an allosteric activator of the M2 isoform of Pyruvate Kinase (PK-M2), the predominant form of pyruvate kinase in cancer cells.
Other Notes:	To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.
Packaging:	1, 5 g in poly bottle
Packaging:	10 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (TLC)
Storage Temp.	−20°C
UNSPSC	12352201

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