Fasentin
SIGMA/F5557 - ≥98% (HPLC)
Synonym: N-
CAS Number: 392721-37-8
Empirical Formula (Hill Notation): C11H9ClF3NO2
Molecular Weight: 279.64
MDL Number: MFCD01001285
Linear Formula: C11H9ClF3NO2
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | white to off-white |
| form | powder |
| InChI | 1S/C11H9ClF3NO2/c1-6(17)4 |
| InChI key | GNYIJZMBLZXJEJ-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | CC(=O)CC(=O)Nc1ccc(Cl)c(c |
| solubility | DMSO: >10 mg/mL |
| storage temp. | room temp |
| Application: | Fasentin has been used as a glucose transporter (GLUT1) inhibitor to assess its effects on the vulnerability of a wide range of triple-negative breast cancer (TNBC) cell lines and to study its effects on cytotoxic drugs induced by hydrocortisone (HC). |
| Biochem/physiol Actions: | Fasentin is a novel inhibitor of glucose uptake, GluT1 inhibitor. Fasentin is a novel inhibitor of glucose uptake that sensitizes cells to FAS-induced cell death. Fasentin selectively sensitized to death ligands, but did not decrease FLIP expression. It alters expression of genes associated with nutrient and glucose deprivation. Fasentin interacted with a unique site in the intracellular channel of the glucose transport protein GLUT1. |
| Biochem/physiol Actions: | Fastentin is a novel inhibitor of glucose uptake, GluT1 inhibitor. |
| Packaging: | 5, 25 mg in glass bottle |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | room temp |
| UNSPSC | 12352200 |