Flavin-Containing Monooxygenase-3, Microsomes human
SIGMA/F5053 - recombinant, expressed in baculovirus infected insect cells, buffered aqueous solution
Synonym: FMO-3
Product Type: Chemical
Flavin Containing Monooxygenase is a broad spectrum monooxygenase. Substrates include primary, secondary and tertiary amines, hydrazines, phosphines, boron, sulfide, selenide, and iodide containing compounds.
| form | buffered aqueous solution |
| mol wt | 55-60 kDa |
| packaging | vial of 2.5 mg |
| Quality Level | 200  |
| recombinant | expressed in baculovirus infected insect cells |
| shipped in | dry ice |
| storage temp. | −70°C |
| UniProt accession no. | P31513  |
| Application: | FMO3 is the major human hepatic form. |
| Biochem/physiol Actions: | Flavin-Containing Monooxygenase-3 (FMO3) facilitates the oxidization of several drugs, chemicals, and xenobiotics. Human FMO3 is also involved in the synthesis of N-oxide of trimethylamine (TMAO) from trimethylamine (TMA). Mutations in the FMO3 gene are associated with trimethylaminuria or fish odor syndrome. Deficiency of the FMO3 gene results in lower plasma TMAO levels, which may reduce the risk of developing atherosclerosis and thrombosis. |
| General description: | Flavin-Containing Monooxygenase-3 (FMO3) is a member of the flavin-containing monooxygenase (FMO) family of enzymes. It is highly expressed in the human liver. |
| Physical form: | Solution in 100 mM potassium phosphate buffer, pH 7.4 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −70°C |
| Enzyme Commission (EC) Number | 1.14.13.8 ( BRENDA | IUBMB ) |
| UNSPSC | 12352204 |