Follicle Stimulating Hormone from human pituitary
SIGMA/F4021 - ~7,000 IU/mg (powder)
Synonym: FSH; Follitropin; FSH
CAS Number: 9002-68-0
MDL Number: MFCD00131099
Product Type: Chemical
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| biological source | human pituitary glands |
| form | powder |
| impurities | HBsAg, HCV and HIV-1/HIV-2, tested negative |
| mol wt | 35 kDa |
| pH | 7.4 |
| Quality Level | 200  |
| shipped in | ambient |
| solubility | water: ~50 g/L |
| specific activity | ~7,000 IU/mg (powder) |
| sterility | non-sterile |
| storage temp. | −20°C |
| technique(s) | cell culture | mammalian: suitable |
| UniProt accession no. | P01225  |
| P23945 |
| Application: | Follicle stimulating hormone (FSH) from human pituitary has been used for- • in vitro luteinization of Macaque granulosa cells • luteal cell proliferation assay • culturing of preantral follicle cells obtained from mice • in vitro maturation of immature cumulus-oocyte complexes (COCs) obtained from mice and • culture of RAW264.7 cell line |
| Biochem/physiol Actions: | FSH (follicle stimulating hormone) in involved in the growth of ovarian follicles and steroidogenesis of ovaries. FSHR (follicle-stimulating hormone receptor) interacts with FSH in the ovaries and determines the responsiveness to this hormone. Depressed levels of FSHR result in poor responsiveness and influence folliculogenesis. In the Caucasian population, certain polymorphisms in the FSHR gene are more commonly found in patients with polycystic ovary syndrome (PCOS). In the male fetuses and neonates, it facilitates the proliferation of Sertoli cells. In pubescent males, it stimulates spermatogonia to undergo mitosis.FSH upon binding to its receptor FSH-R positively regulates G-protein coupled receptors/cyclic adenosine monophosphate (cAMP)/protein kinase A pathways to cascade intracellular signals. |
| Biochem/physiol Actions: | The α-chain is not active; biological specificity is attributed to the β-chain. Induces maturation of Graafian follicles of the ovary; promotes development of germinal cells in males; activates cytosolic tyrosine kinase. |
| General description: | The α chain of FSH has 89 amino acids and the β chain has 115 amino acids. The α chain is not active. FSH belongs to glycoprotein hormone family. It is secreted by the gonadotropic cells of pituitary gland. Research area: Cell signaling |
| Other Notes: | Two-chain glycoprotein hormone |
| Physical form: | Contains 0.1 mg of 0.05M PBS buffer (pH 7.4) |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| activity | specific activity: ~7,000 IU/mg (powder) |
| Storage Temp. | −20°C |
| UNSPSC | 51111800 |