Anti-Fibroblast Growth Factor Receptor-3, Extracellular antibody produced in rabbit
SIGMA/F3922 - affinity isolated antibody, buffered aqueous solution
Synonym: Anti-FGFR-3
MDL Number: MFCD01633348
Product Type: Chemical
Immunohistochemistry Formalin-fixed, paraffin-embedded tissue section of human umbilical cord stained with 1:1,000 Anti-Fibroblast Growth Factor Receptor-3, Extracellular antibody produced in rabbit (Cat. No. F3922) followed by Anti-Rabbit IgG (whole molecule)-Biotin antibody produced in goat (Cat. No. B8895) and by ExtrAvidin®-Peroxidase (Cat. No. E2886).
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | antigen ~120 kDa |
| Quality Level | 200  |
| shipped in | dry ice |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:1,000 using protease-digested, human and animal tissue sections |
| western blot: 1:500 using extract of FGFR-3 transfected cells | |
| UniProt accession no. | P22607  |
| Application: | Anti-Fibroblast Growth Factor Receptor-3, Extracellular antibody produced in rabbit has been used in: • immunoblotting • immunohistochemistry • immunoprecipitation |
| Biochem/physiol Actions: | Fibroblast growth factors (FGFs) are substantially involved in normal development, wound healing and repair, angiogenesis, a variety of neurotrophic activities, and in hematopoiesis as well as in tissue remodeling and maintenance. They have also been implicated in pathological conditions such as tumorigenesis and metastasis. Deletions of chromosome 4p encompassing the FGFR3 (fibroblast growth factor receptor 3) gene cause the Wolf-Hirschhorn syndrome (growth failure, mental retardation, cardiac and bone malformations). Achondroplasia is an inherited disorder in which growth abnormality of bone or cartilage lead to skeletal maldevelopment and dwarfism. It is associated with recurrent mutations of a single amino acid in the transmembrane domain of the FGFR-3 protein. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | FGFR3 (fibroblast growth factor receptor 3) is widely expressed in many fetal and adult human and animal tissues. It belongs to the fibroblast growth factor receptor (Fgfr) family of proteins. It has 19 exons, an extracellular ligand binding domain, a transmembrane domain and an intracellular tyrosine kinase domain. It is located on human chromosome 4p16.3. |
| Immunogen: | synthetic peptide corresponding to amino acids 359-372 of the extracellular region of human fibroblast growth factor receptor-3. |
| Physical form: | Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide. |
| Preparation Note: | Affinity isolated on a peptide-agarose column. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | nwg |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 51111800 |