10058-F4

SIGMA/F3680 - ≥98% (HPLC), solid

Synonym: 5-[(4-Ethylphenyl)methylene]-2-thioxo-4-thiazolidinone

CAS Number: 403811-55-2
Empirical Formula (Hill Notation): C₁₂H₁₁NOS₂
Molecular Weight: 249.35
MDL Number: MFCD00758517
Linear Formula: C₁₂H₁₁NOS₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-F3680-5MG	5 mg	$94.80 1/EA		Add To Favorites
45-F3680-25MG	25 mg	$380.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	yellow
form	solid
InChI	1S/C12H11NOS2/c1-2-8-3-5-9(6-4-8)7-10-11(14)13-12(15)16-10/h3-7H,2H2,1H3,(H,13,14,15)/b10-7+
InChI key	SVXDHPADAXBMFB-JXMROGBWSA-N
Quality Level	100
SMILES string	CCc1ccc(cc1)C=C2SC(=S)NC2=O
solubility	DMSO: >10 mg/mL
	H₂O: <2 mg/mL
storage temp.	2-8°C

Application:	10058-F4 has been used: • as c-Myc inhibitor to treat stromal cells • as c-Myc inhibitor to determine the effect of c-Myc inhibition on cardiac progenitor cells (CPC) growth • as c-Myc inhibitor to culture T cells • to treat C4-2 cells to examine the activity of MST1 promoter luciferase reporter construct
Biochem/physiol Actions:	10058-F4 is a c-Myc inhibitor that induces cell-cycle arrest and apoptosis. 10058-F4 is a cell-permeable thiazolidinone that specificallly inhibits the c-Myc-Max interaction and prevents transactivation of c-Myc target gene expression. 10058-F4 inhibits tumor cell growth in a c-Myc-dependent manner both in vitro and in vivo (64 μM using c-Myc transfected Rat1a fibroblasts).
Biochem/physiol Actions:	10058-F4 is a c-Myc inhibitor.
Features and Benefits:	This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Packaging:	5, 25 mg in glass bottle

Symbol	GHS07
Signal word	Warning
Hazard statements	H317 - H319
Precautionary statements	P280 - P302 + P352 - P305 + P351 + P338
Hazard Codes	Xi
Risk Statements	36-43
Safety Statements	26-36/37
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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