5-Fluoro-2′-deoxyuridine 5′-monophosphate sodium salt

SIGMA/F3503 - ~85%

Synonym: FdUMP

CAS Number: 103226-10-4
Empirical Formula (Hill Notation): C₉H₁₂FN₂O₈P
Molecular Weight: 326.17
MDL Number: MFCD00057409
Linear Formula: C₉H₁₂FN₂O₈P
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-F3503-5MG	5 mg	$301.00 1/EA	Add To Favorites
45-F3503-25MG	25 mg	$1200.00 1/EA	Add To Favorites

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Properties
Descriptions
Safety Info.
Basic Data

assay	~85%
form	solid
InChI	1S/C9H12FN2O8P.Na.H/c10-4-2-12(9(15)11-8(4)14)7-1-5(13)6(20-7)3-19-21(16,17)18;;/h2,5-7,13H,1,3H2,(H,11,14,15)(H2,16,17,18);;
InChI key	DGEOOGBABXVZPJ-UHFFFAOYSA-N
Quality Level	200
SMILES string	[Na].OC1CC(OC1COP(O)(O)=O)N2C=C(F)C(=O)NC2=O
solubility	water: 50 mg/mL, clear, colorless to faint yellow or tan
storage temp.	−20°C

Application:	It has been used: • as an anti-mitotic agent for culturing mouse primary cortical neurons. • as a component of feeding media in the culturing of mouse primary cortical neurons. • in studies on the activity and function of thymidylate synthase (TS).
Biochem/physiol Actions:	5-Fluoro-2′-deoxyuridine 5′-monophosphate sodium salt (FdUMP) is an DNA synthesis inhibitor. FdUMP along with RNA synthesis inhibitor 3′-C-ethinylcytidine induces cell death in cervical cancer cells at nanomolar concentrations.
General description:	5- 5-fluoro-2′-deoxyuridylate (FdUMP) is an intracellularly generated metabolite of 5-Fluorouracil (5-FU), a widely used reagent in molecular biology to study DNA synthesis and metabolism.
Packaging:	25 mg in poly bottle
Packaging:	5 mg in glass bottle

Symbol	GHS07,GHS08
Signal word	Warning
Hazard statements	H302 + H312 + H332 - H351
Precautionary statements	P201 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P308 + P313
Hazard Codes	Xn
Risk Statements	20/21/22-40
Safety Statements	22-36/37/39
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	~85%
Storage Temp.	−20°C
UNSPSC	41106305

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