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Flavopiridol hydrochloride hydrate

SIGMA/F3055 - ≥98% (HPLC), powder

Synonym: (−)-2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-4H-1-benzopyran-4-one hydrochloride; L-86-8276; NSC-649890

CAS Number: 131740-09-5
Empirical Formula (Hill Notation): C21H20ClNO5 ·HCl · xH2O
Molecular Weight: 438.30 (anhydrous basis)
MDL Number: MFCD26792554
Linear Formula: C21H20ClNO5 ·HCl · xH2O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-F3055-5MG 5 mg
 $171.00
1/EA		 Add To Favorites
45-F3055-25MG 25 mg
 $645.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to light brown
form powder
InChI 1S/C21H20ClNO5.ClH/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(19)20)11-4-2-3-5-13(11)22;/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3;1H/t12-,17+;/m0./s1
InChI key LGMSNQNWOCSPIK-LWHGMNCYSA-N
Quality Level 100 
SMILES string OC1=C(C(C=C(C2=C(Cl)C=CC=C2)O3)=O)C3=C([C@H]4CCN(C)C[C@H]4O)C(O)=C1.Cl
solubility DMSO: >5 mg/mL
  H2O: ~2 mg/mL
storage condition desiccated
storage temp. 2-8°C
Application: Flavopiridol hydrochloride hydrate has been used:
• as a cyclin-dependent kinase 9 (CDK9) inhibitor to study its effects on histone H3 methylation at lysine 36 (H3K36) and deactivation of transcription in porcine fetal fibroblasts
• as an RNA polymerase inhibitor to study its effects on hepatic cells
• as RNA transcription inhibitor to study its effects on euchromatin coarsening in zebrafish embryo
Biochem/physiol Actions: Flavopiridol hydrochloride is a potent CDK (cyclin-dependent kinase), and a CDC25 phosphatase family inhibitor.
Biochem/physiol Actions: Flavopiridol is a semi-synthetic flavone obtained from Dysoxylum binectariferum that acts as an anti-tumor agent against several cancers. It also shows anti-cancer properties due to which it has been studied in the treatment of acute myeloid leukemia (AML).
Features and Benefits: This compound is featured on the CDKs  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging: 5, 25 mg in glass bottle
Symbol GHS07  GHS07
Signal word Warning
Hazard statements H302
Hazard Codes Xn
Risk Statements 22
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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