Follistatin 288 from mouse
SIGMA/F2177 - >95% (SDS-PAGE), recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder
Synonym: FS-288
MDL Number: MFCD03456879
Product Type: Chemical
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| assay | >95% (SDS-PAGE) |
| biological source | mouse |
| form | lyophilized powder |
| impurities | endotoxin, tested |
| mol wt | calculated mol wt ~31 kDa |
| packaging | pkg of 25 μg |
| potency | 0.04-0.4 mg per mL |
| Quality Level | 100  |
| recombinant | expressed in baculovirus infected Sf21 cells |
| storage condition | avoid repeated freeze/thaw cycles |
| storage temp. | −20°C |
| UniProt accession no. | P47931  |
| Analysis Note: | The biological activity is measured by its ability to neutralize activin-induced erythroid differentiation on K562 cells. |
| Biochem/physiol Actions: | FST (follistatin) binds to and regulates activins, which in turn are TGF (transforming growth factor)-β superfamily members. The expression level of FST and its binding partner activin A is elevated in inflammatory disorders. The activin A-follistatin system plays an essential role in the modulation of glucose and lipid metabolism, which might have an overall effect on fetal growth. In adipose tissue, it facilitates the adipogenic differentiation of progenitor cells. |
| Biochem/physiol Actions: | High affinity activin-binding protein that can act as an activin antagonist. |
| General description: | FST (follistatin) is an activin-binding protein, and exists in two isoforms due to alternate splicing, FS288 and FS315. It is a glycoprotein with a single chain, and acts as an activin antagonist. It has a high level of expression in fetal membranes and placenta. |
| Packaging: | 25 μg in glass insert |
| Physical form: | Recombinant Mouse Follistatin 288 is supplied as a approximately 25 μg of protein lyophilized from a 0.2 μm filtered solution in 30% acetonitrile and 0.1% TFA containing 1.25 mg of bovine serum albumin. |
| Symbol |  GHS05 |
| Signal word | Danger |
| Hazard statements | H315 - H318 |
| Precautionary statements | P280 - P305 + P351 + P338 + P310 |
| Hazard Codes | Xi |
| Risk Statements | 36/38 |
| Safety Statements | 22-26-37-60 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | >95% (SDS-PAGE) |
| Storage Temp. | −20°C |
| UNSPSC | 51111800 |