Anti-FOXL2 antibody produced in rabbit
SIGMA/F0805 - affinity isolated antibody
Synonym: Anti-Forkhead L2; Anti-Forkhead Transcription Factor
MDL Number: MFCD09039192
Product Type: Chemical
This image is provided for informative purposes only and does not represent an actual product label. It should not be used as a substitute for official product labeling.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| Quality Level | 200  |
| shipped in | dry ice |
| species reactivity | mouse, hamster |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): 0.2 μg/mL using murine prenatal folicle |
| indirect immunofluorescence: 2 μg/mL using KK1 granulosa cells | |
| western blot: 0.2 μg/mL using CHO whole cell lysate | |
| UniProt accession no. | O88470  |
| Application: | Anti-FOXL2 antibody produced in rabbit is suitable for the following applications: • Immunohistochemistry (formalin-fixed, paraffin-embedded sections) at a concentration of 0.2μg/mL using murine prenatal folicle • Indirect immunofluorescence at a concentration of 2μg/mL using KK1 granulosa cells • Western blotting (at a concentration of 0.2μg/mL using CHO whole cell lysate) or immunoblot analysis. |
| Biochem/physiol Actions: | Forkhead box protein L2 is a protein encoded by the FOXL2 gene in humans. The gene FOXL2 encodes a member of the fork-head-winged-helix family of transcription factors. It is expressed early during female gonadal development and is expressed in normal ovarian stroma and ovarian neoplasms with granulosa cell lineage. FOXL gene encodes an essential transcription factor in the ovary and helps in female sex determination, follicle recruitment and granulosa cell development. Its mutation is specific to AGCTs in the ovary and is useful for diagnosis of disease. FOXL2 acts as an oncogene or tumour suppressor depending on the genetic context that is the GCT subtype. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | FOXL2 encodes a forkhead transcription factor. The protein contains a fork-head DNA-binding domain and may play a role in ovarian development and function. Mutations in this gene are a cause of blepharophimosis syndrome and premature ovarian failure 3. |
| Immunogen: | synthetic peptide M(1)MASYPEPEDTAGT(14) corresponding to amino acid residues 1-14 from mouse FOXL2. This sequence is completely conserved in mouse and rat and 92% conserved in human. |
| Physical form: | Provided as 100 μg of affinity purified IgG (1 mg/mL) in phosphate buffered saline containing 1 mg/mL bovine serum albumin and 0.05% sodium azide. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |