Folate binding protein from bovine milk
SIGMA/F0504 - lyophilized powder
Synonym: Folate Protein
MDL Number: MFCD00131098
Product Type: Chemical
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| biological source | bovine milk |
| capacity | 1.5-6.0 μg/mg, protein binding capacity (folic acid)(25 °C at pH 7.5.) |
| composition | Protein, 20-40% modified Warburg-Christian |
| form | lyophilized powder |
| Quality Level | 200  |
| storage temp. | −20°C |
| technique(s) | ligand binding assay: suitable |
| surface plasmon resonance (SPR): suitable | |
| usage | mg sufficient for ~4,000 assays |
| Analysis Note: | Purified over 1,000 fold. May contain a trace of β-mercaptoethanol. |
| Application: | Folate binding protein can be used in radioligand binding assays of serum folate. The folate receptor has been used in studies as a therapeutic target in a variety of cancers. |
| Application: | Folate binding protein from bovine milk has been used in folate binding studies using surface plasmon resonance and in the uptake studies in kidney proximal tubule cells. |
| Application: | Useful for radioligand binding assays of serum folate. May also bind N-methyltetrahydrofolic acid and other folate analogues. |
| Biochem/physiol Actions: | Folate-binding protein (FBP) is present as a cell receptor and binds to folate in equimolar ratio. It is involved in the transport of folate and improves their bioavailability. |
| Packaging: | 1, 5 mg in glass bottle |
| Packaging: | Package size based on protein content |
| Physical form: | Lyophilized powder containing buffer salt as sodium citrate |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352202 |