5-Fluoro-2′-deoxyuridine
SIGMA/F0503 - thymidylate synthase inhibitor
Synonym: floxuridine; 2′-Deoxy-5-fluorouridine; FUDR; Floxuridine
CAS Number: 50-91-9
Empirical Formula (Hill Notation): C9H11FN2O5
Molecular Weight: 246.19
EC Number: 200-072-5
MDL Number: MFCD00006530
Linear Formula: C9H11FN2O5
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: F0503-100MG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: F0503-1G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: F0503-250MG
| assay | ≥99% (HPLC) |
| biological source | synthetic (organic) |
| form | powder |
| InChI | 1S/C9H11FN2O5/c10-4-2-12( |
| InChI key | ODKNJVUHOIMIIZ-RRKCRQDMSA |
| mp | 148 °C (lit.) |
| Quality Level | 200  |
| SMILES string | OC[C@H]1O[C@H](C[C@@H]1O) |
| solubility | water: 50 mg/mL, clear, colorless to faintly yellow |
| storage temp. | room temp |
| Application: | 5-Fluoro-2′-deoxyuridine has been used as a mitotic inhibitor in schwann cell proliferation, glia proliferation and nonneuronal cells in dorsal root ganglion cultures. |
| Biochem/physiol Actions: | Antineoplastic drug that acts as a potent inhibitor of thymidylate synthetase Resistance to FUdR can develop in cancer cell cultures, among other means, by low-level Mycoplasma infection. |
| General description: | 5-Fluoro-2′-deoxyuridine, also called floxuridine elicits DNA-directed cytotoxicity in cancer cells. Floxuridine is effective for treating liver cancer and eliminating virulence of Staphylococcus aureus. Dipeptide prodrugs combination of floxuridine with gemcitabine are more cell permeable and display enhanced anti-proliferative activity. Floxuridine is effective on solid tumours and advanced stage cancers. |
| Packaging: | 1 g in poly bottle |
| Packaging: | 100, 250 mg in poly bottle |
| Symbol |  GHS06 |
| Signal word | Danger |
| Hazard statements | H301 |
| Precautionary statements | P301 + P330 + P331 + P310 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| Safety Statements | 22-36 |
| RIDADR | UN 2811 6.1 / PGIII |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥99% (HPLC) |
| mp | 148 °C (lit.) |
| Storage Temp. | room temp |
| UNSPSC | 12352202 |