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Fenobam

SIGMA/F0430 - ≥98% (HPLC), solid

Synonym: N-(3-Chlorophenyl)-N′-(4,5-dihydro-1-methyl-4-oxo-1H-imidazole-2-yl)urea

CAS Number: 57653-26-6
Empirical Formula (Hill Notation): C11H11ClN4O2
Molecular Weight: 266.68
MDL Number: MFCD00868019
Linear Formula: C11H11ClN4O2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-F0430-5MG 5 mg
 $136.00
1/EA		 Add To Favorites
45-F0430-25MG 25 mg
 $508.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white
form solid
InChI 1S/C11H11ClN4O2/c1-16-6-9(17)14-10(16)15-11(18)13-8-4-2-3-7(12)5-8/h2-5H,6H2,1H3,(H2,13,14,15,17,18)
InChI key DWPQODZAOSWNHB-UHFFFAOYSA-N
originator Johnson & Johnson
Quality Level 100 
SMILES string CN1CC(=O)N=C1NC(=O)Nc2cccc(Cl)c2
solubility DMSO: >20 mg/mL
storage temp. 2-8°C
Biochem/physiol Actions: Fenobam is a potent, selective, noncompetitive glutamate mGluR5 receptor antagonist. Fenobam displays inverse agonist properties; blocks mGluR5 constitutive activity in vitro (IC50 = 87 nM, slightly weaker than MPEP). Fenobam acts at an allosteric modulatory site shared with MPEP and binds the mGlu5 receptor with Kd values of 54 and 31 nM for rat and human receptors, respectively. Fenobam belongs to a structurally different class than MPEP; devoid of GABAergic activity and thus typical benzodiazepine-like side effects; displays anxiolytic activity.
Biochem/physiol Actions: Potent, selective, noncompetitive metabotropic glutamate receptor antagonist (mGluR5). Displays anxiolytic activity.
Features and Benefits: This compound is a featured product for Neuroscience research. Click here  to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits: This compound is featured on the Glutamate Receptors (G Protein Family)  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Features and Benefits: This compound was developed by Johnson & Johnson . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Packaging: 5, 25 mg in glass bottle
Hazard Codes T
Risk Statements 25
Safety Statements 45
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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