β-Estradiol

SIGMA/E2758 - BioReagent, powder, suitable for cell culture

Synonym: 1,3,5-Estratriene-3,17β-diol; 17β-Estradiol; 3,17β-Dihydroxy-1,3,5(10)-estratriene; Dihydrofolliculin

CAS Number: 50-28-2
Empirical Formula (Hill Notation): C₁₈H₂₄O₂
Molecular Weight: 272.38
EC Number: 200-023-8
MDL Number: MFCD00003693
Linear Formula: C₁₈H₂₄O₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-E2758-250MG	250 mg	$47.80 1/EA	Add To Favorites
45-E2758-1G	1 g	$118.00 1/EA	Add To Favorites
45-E2758-5G	5 g	$452.00 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: E2758-1G

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
biological source	synthetic (organic)
form	powder
InChI	1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1
InChI key	VOXZDWNPVJITMN-ZBRFXRBCSA-N
mp	176-180 °C (lit.)
product line	BioReagent
Quality Level	200
shipped in	ambient
SMILES string	O[C@H]1CC[C@@]2([H])[C@]3([H])CCC4=CC(O)=CC=C4[C@@]3([H])CC[C@@]21C
solubility	ethanol: 50 mg/mL, clear, colorless
storage temp.	room temp
technique(s)	cell culture \| mammalian: suitable
	single cell analysis: suitable

Application:	β-Estradiol is used to study cell differentiation and transformations (tumorigenicity).
Application:	β-Estradiol has been used: • as a component of Dulbecco′s modified Eagle medium (DMEM) for culturing mammary tumor cells • as a oestrogenic compound for testing neuroprotective effects • as a component of medium199 for culturing oocytes
Biochem/physiol Actions:	The major estrogen secreted by the premenopausal ovary.
Biochem/physiol Actions:	The major estrogen secreted by the premenopausal ovary. Estrogens direct the development of the female phenotype in embryogenesis and during puberty by regulating gene transcription and, thus, protein synthesis. It also induces the production of gonadotropins which, in turn, induce ovulation. Exposure to estradiol increases breast cancer incidence and proliferation.
Biochem/physiol Actions:	β-Estradiol (E2) is a major premenopausal hormone in women and is essential for spermiogenesis, sperm maturation and motility in men. Cultured bone marrow stem cells (BMSCs) have ability to synthesize E2 and could be exploited for treating estrogen deficiency. It mediates physiological functions through estrogen receptor (ER) α and ERβ.
General description:	β-Estradiol or estradiol-17 β (E2) is secreted majorly by the large preovulatory follicles in the ovary. In addition, estradiol can be synthesized de novo from cholesterol have androgens synthesized from cholesterol. The aromatization of androgen by enzyme aromatase (P450arom) results in the β-estradiol production.
Packaging:	1, 5 g in glass bottle
Packaging:	250 mg in glass bottle
Physical form:	powder-RT; stock-frozen in working aliquots, avoid repeated freeze/thaw
Preparation Note:	To prepare a 20 μg/ml stock solution, add 1 ml absolute ethanol to 1 mg β-estradiol; gently swirl to dissolve; add 49 ml sterile medium while mixing.

Symbol	GHS08,GHS09
Signal word	Danger
Hazard statements	H351 - H360FD - H362 - H410
Precautionary statements	P202 - P260 - P263 - P264 - P273 - P308 + P313
Hazard Codes	T
Risk Statements	60-63-40-64
Safety Statements	53-45
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
mp	176-180 °C (lit.)
Storage Temp.	room temp
UNSPSC	12352209

To Order From a Quote