Deferoxamine mesylate salt
SIGMA/D9533 - powder, ≥92.5% (TLC)
Synonym: DFX mesylate; DFOM; Deferoxamine methanesulfonate salt; Desferrioxamine mesylate salt
CAS Number: 138-14-7
Empirical Formula (Hill Notation): C25H48N6O8 · CH4O3S
Molecular Weight: 656.79
EC Number: 205-314-3
MDL Number: MFCD00058605
Linear Formula: C25H48N6O8 · CH4O3S
Product Type: Chemical
| assay | ≥92.5% (TLC) |
| color | white to off-white |
| form | powder |
| InChI | 1S/C25H48N6O8.CH4O3S/c1-2 |
| InChI key | IDDIJAWJANBQLJ-UHFFFAOYSA |
| Quality Level | 200  |
| SMILES string | CS(O)(=O)=O.CC(=O)N(O)CCC |
| solubility | H2O: 50 mg/mL |
| storage temp. | −20°C |
| Application: | Deferoxamine mesylate salt has been used • for cell pretreatment to assess its influenceon cell viability and its interactions with other compounds () • to study the effect on Lipocalin 2(Lcn2) production triggered by amyloid-β(Aβ). () • used to induce iron starvation in bacterial cultures.() |
| Biochem/physiol Actions: | An iron chelator used often in the studies of cell proliferation and apoptosis. Also reported to induce p53. |
| Biochem/physiol Actions: | An iron chelator used often in the studies of cell proliferation and apoptosis. Has been shown to have anti-proliferative effects on vascular smooth muscle cells in vitro and in vivo and to arrest cells in the G1 phase. Also reported to induce p53. Induces apoptosis in HL-60 cells by chelating iron. After 48 hrs treatment with 1μM deferoxamine, DNA fragmentation was apparent. Cells treated with 0.1 μM deferoxamine for as little as 24 hours were committed to apoptosis; by 48 hrs nuclear collapse was observed. In some studies it has been shown to have antioxidant properties and to protect cells against H2O2-induced damage. |
| Biochem/physiol Actions: | Deferoxamine is used as a hypoxia-mimetic agent to stabilize Hypoxia Inducible Factor 1 (HIF-1). Deferoxamine stabilizes HIF-1 through the inhibition of Prolyl Hydroxylases (PHDs) which target HIF-1 through degradation. The mechanism of deferoxamine inhibition is likely through the chelation of Fe2+ bound to the active site of PHD which is required for enzymatic activity. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥92.5% (TLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352116 |