DAPT

SIGMA/D5942 - ≥98% (HPLC), solid

Synonym: GSI-IX; LY-374973; N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester

CAS Number: 208255-80-5
Empirical Formula (Hill Notation): C₂₃H₂₆F₂N₂O₄
Molecular Weight: 432.46
MDL Number: MFCD04974585
Linear Formula: C₂₃H₂₆F₂N₂O₄
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-D5942-5MG	5 mg	$266.00 1/EA	Add To Favorites
45-D5942-25MG	25 mg	$944.00 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: D5942-25MG

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
biological source	synthetic (organic)
color	white
form	solid
InChI	1S/C23H26F2N2O4/c1-14(26-19(28)12-15-10-17(24)13-18(25)11-15)21(29)27-20(16-8-6-5-7-9-16)22(30)31-23(2,3)4/h5-11,13-14,20H,12H2,1-4H3,(H,26,28)(H,27,29)/t14-,20+/m0/s1
InChI key	DWJXYEABWRJFSP-VBKZILBWSA-N
originator	Eli Lilly
Quality Level	100
SMILES string	C[C@H](NC(=O)Cc1cc(F)cc(F)c1)C(=O)N[C@@H](C(=O)OC(C)(C)C)c2ccccc2
solubility	DMSO: ~18 mg/mL
storage temp.	2-8°C

Application:	DAPT has been used: as acomponent in neuronal differentiation medium (NDM) to initiate cortical neuronpatterning, as a Notch signaling inhibitor to study its effects on hair cellregeneration in zebrafish, as a γ-secretase inhibitor to block the Notchpathway to evaluate its effects on rat pulmonary artery smooth muscle cells(PASMC) proliferation
Biochem/physiol Actions:	γ-secretase inhibitor, blocks Notch signaling.
Biochem/physiol Actions:	DAPT is a γ-secretase inhibitor and indirectly an inhibitor of Notch, a γ-secretase substrate. Other γ-secretase substrates include LDL receptor-related protein, E-cadherin and ErbB-4. As an inhibitor of γ-secretase, DAPT may be useful in the study of β-amyloid (Aβ) formation. DAPT has been shown to inhibit Notch signaling in studies of autoimmune and lymphoproliferative diseases, such as ALPS and lupus erythematosus (SLE), as well as in cancer cell growth, angiogenesis, and differentiation of human induced pluripotent stem cells (hIPSC).
Features and Benefits:	This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits:	This compound was developed by Eli Lilly . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Packaging:	25 mg in poly bottle
Packaging:	5 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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