Dexamethasone-Water Soluble

SIGMA/D2915 - BioReagent, suitable for cell culture

Synonym: Dexamethasone – Cyclodextrin complex

CAS Number: 50-02-2
EC Number: 200-003-9
MDL Number: MFCD00064136
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-D2915-100MG	100 mg	$198.00 1/EA	Add To Favorites

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Properties
Descriptions
Safety Info.
Basic Data

biological source	synthetic (organic)
form	solid
InChI	1S/C42H70O35.C22H30O4/c43-1-8-29-15(50)22(57)36(64-8)72-30-9(2-44)66-38(24(59)17(30)52)74-32-11(4-46)68-40(26(61)19(32)54)76-34-13(6-48)70-42(28(63)21(34)56)77-35-14(7-49)69-41(27(62)20(35)55)75-33-12(5-47)67-39(25(60)18(33)53)73-31-10(3-45)65-37(71-29)23(58)16(31)51;1-12-8-16-15-5-4-13-9-14(24)6-7-21(13,2)20(15)17(25)10-22(16,3)19(12)18(26)11-23/h8-63H,1-7H2;6-7,9,12,15-17,19-20,23,25H,4-5,8,10-11H2,1-3H3/t8-,9-,10-,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31-,32-,33-,34-,35-,36-,37-,38-,39-,40-,41-,42-;12-,15+,16?,17+,19-,20-,21+,22+/m11/s1
InChI key	XEJNDGTUKUMQNG-ARJMFYCQSA-N
product line	BioReagent
Quality Level	200
shipped in	ambient
SMILES string	C[C@@H]1CC2C3CCC4=CC(=O)C=C[C@]4(C)C3[C@@H](O)C[C@]2(C)[C@H]1C(=O)CO.OC[C@H]5O[C@@H]6O[C@H]7[C@H](O)[C@@H](O)[C@H](O[C@@H]7CO)O[C@H]8[C@H](O)[C@@H](O)[C@H](O[C@@H]8CO)O[C@H]9[C@H](O)[C@@H](O)[C@H](O[C@@H]9CO)O[C@H]%10[C@H](O)[C@@H](O)[C@H](O[C@@H]%10CO)O[C@H]%11[C@H](O)[C@@H](O)[C@H](O[C@@H]%11CO)O[C@H]%12[C@H](O)[C@@H](O)[C@H](O[C@@H]%12CO)O[C@H]5[C@H](O)[C@H]6O
solubility	H₂O: 25 mg/mL, clear to slightly hazy
storage temp.	room temp
technique(s)	cell culture \| mammalian: suitable

Application:	Dexamethasone-Water Soluble has been used as a component of • Dulbecco′s modified Eagle medium based osteogenic and adipogenic medium for human mesenchymal stem cell culture • erythroid expansion media for the growth of liver, bone marrow and spleen tissues • medium 199 (M199) for hepatocyte culture
Biochem/physiol Actions:	Dexamethasone is an anti-inflammatory glucocorticoid and a synthetic corticosteroid used for treating corneal inflammation. It inhibits the IL-1β-dependent angiogenesis. Dexamethasone elicits a range of effects on cell survival, cell signaling and gene expression. It favors apoptosis in chondrocytes and impairs development of bone. Dexamethasone is a potential therapeutic agent as it induces apoptosis in multiple myeloma (MM) cells. It elicits its functionality by lowering glucocorticoid receptor (GR) α levels and inhibits colon tumor progression.
Other Notes:	Contains approx. 65 mg dexamethasone per gram; balance methyl-β-cyclodextrin.
Packaging:	100 mg in glass bottle
Packaging:	Package size based on dexamethasone

Symbol	GHS08
Signal word	Danger
Hazard statements	H360FD
Precautionary statements	P201 - P202 - P280 - P308 + P313 - P405 - P501
Hazard Codes	Xn
Risk Statements	36/37/38-42/43
Safety Statements	22-26-36/37-45
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Storage Temp.	room temp
UNSPSC	12352209

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