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6-Diazo-5-oxo-L-norleucine

SIGMA/D2141 - powder

Synonym: (S)-2-Amino-6-diazo-5-oxocaproic acid; DON

CAS Number: 157-03-9
Empirical Formula (Hill Notation): C6H9N3O3
Molecular Weight: 171.15
MDL Number: MFCD00037218
Linear Formula: C6H9N3O3
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-D2141-5MG 5 mg
 $76.00
1/EA		 Add To Favorites
45-D2141-25MG 25 mg
 $263.00
1/EA		 Add To Favorites

 

antibiotic activity spectrum neoplastics
assay ≥95% (HPLC)
color faint yellow, to yellow or tan
form powder
InChI 1S/C6H9N3O3/c7-5(6(11)12)2-1-4(10)3-9-8/h3,5H,1-2,7H2,(H,11,12)/t5-/m0/s1
InChI key YCWQAMGASJSUIP-YFKPBYRVSA-N
mode of action enzyme | inhibits
Quality Level 200 
SMILES string N[C@@H](CCC(=O)C=[N+]=[N-])C(O)=O
storage temp. −20°C
technique(s) ligand binding assay: suitable
Application: 6-Diazo-5-oxo-L-norleucine (DON) has been used as an inhibitor of glutamine synthetase–glutamine(amide)-2-oxoglutarate aminotransferase.
Biochem/physiol Actions: 6-Diazo-5-oxo-L-norleucine (DON), a glutamine analogue, is used as an inhibitor to study the function, specificity and characteristics of cytidine triphosphate synthase 1(s) (CTPS1) and various glutaminase(s). DON is used to inhibit glutamine (GLN) flux between cells.
Biochem/physiol Actions: DON is associated with a number of reactions involving L-glutamine as a nitrogen source, such as nucleic acid and protein synthesis. It is known to possess anticancer activity against choriocarcinoma.
Biochem/physiol Actions: DON is used to study mechanisms of glutamine utilizing enzymes such as carbamoyl phosphate synthase and cytidine triphosphate synthase.
General description: Chemical structure: amino acid derivatives
Purity ≥95% (HPLC)
Storage Temp. −20°C
UNSPSC 12352209

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