Chorionic gonadotropin human
SIGMA/CG10 - lyophilized powder, vial of ~10,000 IU
Synonym: Choriogonin; HCG
CAS Number: 9002-61-3
MDL Number: MFCD00130797
Product Type: Chemical
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| biological source | human urine |
| contains | mannitol |
| drug control | Home Office Schedule 4.2 |
| form | lyophilized powder |
| impurities | HBsAg, HCV and HIV-1/HIV-2, tested negative |
| mol wt | 37.9 kDa |
| packaging | vial of ~10,000 IU |
| Quality Level | 200  |
| shipped in | ambient |
| solubility | water: 10 mL/vial, clear to slightly hazy, colorless |
| sterility | sterile-filtered |
| storage temp. | −20°C |
| UniProt accession no. | P01215  |
| Analysis Note: | The calculated value is based on the USP method for human Chorionic Gonadotrophin, to meet 10,000 IU per vial, with a tolerance of not less than 80.0% and not more than 125.0% of the potency stated. |
| Application: | Chorionic gonadotropin has been used: • in in vitro analysis of cytotoxicity • in egg and embryo preparations • in the superovulation of CD-1 mice • in gonadotropin preparations for the in vivo studies with the luteinizing hormone-releasing hormone (LHRH) agonist (LHRH-a) to synchronize naturally cycling rats. |
| Biochem/physiol Actions: | Human chorionic gondadotropin (hCG) may be used as an alternative to PMSG to induce ovulation in laboratory animals. When hCG was injected into laboratory animals via intravenous (i.v.), intraperitoneal (i.p.), or subcutaneous (s.c.) methodstet, the effective dose values for 50% of the animals (ED50) per animal and per body weight (kg) in parenthesis were as follows: Mice: i.v. 0.2 (7.7) I.U.; i.p. 0.3 (11.5) I.U.; s.c. 0.7 (26.9) I.U. Syrian hamsters: i.v. 1.0 (9.5) I.U.; i.p. 1.8 (17.1) I.U.; s.c. 2.6 (24.8) I.U. Rats: i.v. 1.3 (4.6) I.U.; i.p. 3.5 (12.3) I.U.; s.c.7.5 (26.3) I.U. Using PMSG, the ED50 values per animal and per body weight (kg) in parenthesis were as follows: Mice: i.v. 0.8 (30.8) I.U.; i.p. 2.0 (76.9) I.U.; s.c. 2.8 (107.7) I.U Syrian hamsters: i.v., 3.6 (34.3) I.U.; i. p., 8.0 (76.2) I.U.; s.c., 13.2 (125.7) I.U. Rats: i.v., 6.0 (76.8) I.U.; i p., 20.8 (73.0) I.U.; s.c., 76.8 (269.5) I.U. |
| General description: | Glycoprotein hormone consisting of a 92-amino acid α-chain which is identical to that of LH, FSH, and TSH; and a distinct 149-amino acid β-chain. Produced by chorionic tissue and responsible for maintaining the corpus luteum during early pregnancy. Also produced by trophoblast cell neoplasms, which are marked by elevated free hCG β-chains and hyperglycosylated hCG. |
| Preparation Note: | When reconstituted with 10 mL water to a concentration of 1,000 IU/mL, the vial will also contain 0.01 M sodium phosphate buffer (pH approx. 7.2) and 10 mg/mL of mannitol. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352209 |