Monoclonal Anti-CD152 antibody produced in mouse
SIGMA/C9979 - ~1 mg/mL, clone AS32, purified immunoglobulin, buffered aqueous solution
Synonym: Anti-CTLA-4
MDL Number: MFCD01864928
Product Type: Chemical
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| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| biological source | mouse |
| clone | AS32, monoclonal |
| concentration | ~1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| isotype | IgG1 |
| Quality Level | 200  |
| shipped in | wet ice |
| species reactivity | human |
| storage temp. | 2-8°C |
| target post-translational modification | unmodified |
| technique(s) | neutralization: suitable |
| western blot: suitable | |
| UniProt accession no. | P16410  |
| Application: | Monoclonal Anti-CD152 antibody produced in mouse is suitable for western blotting and for neutralization studies, where this antibody has been shown to block the interaction of soluble human CD152 with human CD80. |
| Biochem/physiol Actions: | CD152 and CD28 together with their ligands constitute one of the dominant co-stimulatory pathways that regulate T- and B-cell responses. CD152 acts as a co-stimulatory molecule in eliciting T cell help during antigen presentation and functions as a negative regulator of T cell activation. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | CD152 is structurally similar to CD28 and is a member of the immunoglobin (Ig) gene superfamily. The gene encoding human CD152 is present on chromosone 2. It is composed of a single Ig V-like extracellular domain, a transmembrnne domain, and an intracellular domain. It is mainly expressed by cytotoxic T lymphocytes and the level of expression is activation-dependent. |
| General description: | CD152, a cell surface glycoprotein, is one of two ligands (the other is CD28) for CD80 (B7-1) and CD86 (B7-2). This interaction appears to function as a negative regulator to T cell activation. CD152 is transiently expressed on activated T cells. |
| Immunogen: | recombinant extracellular domain of human CD152. |
| Physical form: | Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 0.08% sodium azide. |
| Preparation Note: | Prepared from tissue culture supernatant, purified using protein G. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352203 |