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CPTH2

SIGMA/C9873 - ≥98% (HPLC), powder

Synonym: Cyclopentylidene-[4-(4-chlorophenyl)thiazol-2-yl)hydrazone

CAS Number: 357649-93-5
Empirical Formula (Hill Notation): C14H14ClN3S
Molecular Weight: 291.80
MDL Number: MFCD02307488
Linear Formula: C14H14ClN3S
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-C9873-5MG 5 mg
 $192.00
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assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C14H14ClN3S/c15-11-7-5-10(6-8-11)13-9-19-14(16-13)18-17-12-3-1-2-4-12/h5-9H,1-4H2,(H,16,18)
InChI key YYTHPXHGWSAKIZ-UHFFFAOYSA-N
Quality Level 100 
SMILES string Clc1ccc(cc1)-c2csc(NN=C3CCCC3)n2
solubility DMSO: >10 mg/mL
storage temp. 2-8°C
Application: CPTH2 has been used for the inhibition of histone acetyltransferase in cortical cultures, bud cells and natural killer T cells (iNKT).
Biochem/physiol Actions: CPTH2 is a histone acetyltransferase (HAT) inhibitor modulating the Gcn5 network.
Biochem/physiol Actions: CPTH2 is a histone acetyltransferase (HAT) inhibitor modulating the Gcn5 network. Histone Acetyltransferase (HAT) inhibitor modulating Gcn5 network. Histone acetyltransferases (HATs) act as transcriptional coactivators. Histone acetylation plays an important role in regulating the chromatin structure and is tightly regulated by two classes of enzyme, histone acetyltransferases (HAT) and histone deacetylases (HDAC). Deregulated HAT and HDAC activity plays a role in the development of a range of cancers. Consequently, inhibitors of these enzymes have potential as anticancer agents.
Features and Benefits: This compound is a featured product for Gene Regulation research. Click here  to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
General description: CPTH2 ((3-methylcyclopentylidene-[4-(4′-chlorophenyl)thiazol-2-yl]hydrazone)) inhibits histone acetyltransferase functionality and reduces acetylation of histone H3 and H4. CPTH2 promotes apoptosis in lymphoma cell lines. It may serve as an anticancer agent. CPTH2 inhibits α-tubulin acetylation and modulates autophagic pathway in human acute myeloid leukemia cell lines.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany nwg
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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