Casein, N,N-dimethylated from bovine milk

SIGMA/C9801 - essentially salt-free, lyophilized powder

Synonym: N,N-dimethylcasein

CAS Number: 9000-71-9
MDL Number: MFCD00130742
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-C9801-1G	1 g	$69.10 1/EA	Add To Favorites
45-C9801-5G	5 g	$190.00 1/EA	Add To Favorites
45-C9801-25G	25 g	$685.00 1/EA	Add To Favorites
45-C9801-50G	50 g	$1120.00 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: C9801-1G

Properties
Descriptions
Safety Info.
Basic Data

assay	≥90% (colorimetric)
biological source	bovine milk
form	essentially salt-free, lyophilized powder
InChI	1S/C81H125N22O39P/c1-36(2)31-50(76(132)94-43(15-24-57(87)108)71(127)101-52(34-64(120)121)78(134)98-49(81(137)138)11-7-8-30-82)99-72(128)47(19-28-61(114)115)95-77(133)51(33-63(118)119)100-73(129)48(20-29-62(116)117)97-80(136)65(37(3)104)103-75(131)44(16-25-58(88)109)92-68(124)42(14-23-56(86)107)90-67(123)41(13-22-55(85)106)91-69(125)45(17-26-59(110)111)93-70(126)46(18-27-60(112)113)96-79(135)53(35-142-143(139,140)141)102-74(130)40(12-21-54(84)105)89-66(122)39(83)32-38-9-5-4-6-10-38/h4-6,9-10,36-37,39-53,65,104H,7-8,11-35,82-83H2,1-3H3,(H2,84,105)(H2,85,106)(H2,86,107)(H2,87,108)(H2,88,109)(H,89,122)(H,90,123)(H,91,125)(H,92,124)(H,93,126)(H,94,132)(H,95,133)(H,96,135)(H,97,136)(H,98,134)(H,99,128)(H,100,129)(H,101,127)(H,102,130)(H,103,131)(H,110,111)(H,112,113)(H,114,115)(H,116,117)(H,118,119)(H,120,121)(H,137,138)(H2,139,140,141)
InChI key	BECPQYXYKAMYBN-UHFFFAOYSA-N
Quality Level	200
SMILES string	[P](=O)(OCC(NC(=O)C(NC(=O)C(N)Cc1ccccc1)CCC(=O)N)C(=O)NC(CCC(=O)O)C(=O)NC(CCC(=O)O)C(=O)NC(CCC(=O)N)C(=O)NC(CCC(=O)N)C(=O)NC(CCC(=O)N)C(=O)NC(C(O)C)C(=O)NC(CCC(=O)O)C(=O)NC(CC(=O)O)C(=O)NC(CCC(=O)O)C(=O)NC(CC(C)C)C(=O)NC(CCC(=O)N)C(=O)NC(CC(=O)O)C(=O)NC(C
storage temp.	−20°C
technique(s)	activity assay: suitable
UniProt accession no.	P02662
	P02663
	P02666
	P02668

Application:	Casein, N,N-dimethylated from bovine milk has been used: • in the determination of general proteolytic activity • as a substrate to study the effect of dephosphorylation on the calcium-activated neutral proteases (CANP) proteolysis of paired helical filaments (PHF) II-τ • in transglutaminase (TG) assay
Application:	Casein, N,N-dimethylated from bovine milk can be used in assays to detect and help determine the functional role of tissue transglutaminase (tTG) in disease. In particular, Casein, N,N-dimethylated has been used in the mechanic and kinetic analysis of tTG on protein substrates, which may be linked to neurodegenerative disease. This preparation has less than 10% reactivity with 2,4,6-trinitrobenzenesulfonic acid (TNBS) compared to non-methylated casein. Protease substrate that has been used to assay basilase and a subtilisin analog that had been produced by site-directed mutagenesis.
Biochem/physiol Actions:	Casein is highly preferred as a drug delivery vehicle. It possess antioxidant activity.
General description:	Casein is a milk protein, that is not expensive and nontoxic. highly stable. This phosphoproteins accounts for 80% of the total protein present in bovine milk. Casein is a member of one of the larger family of secretory calcium?binding phosphoproteins.
Packaging:	1, 5, 25, 50 g in poly bottle
Preparation Note:	Reductive methylation of C5890 by the method of Cabacungan, J.C., et al., Anal. Biochem., 124, 272 (1982).

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥90% (colorimetric)
Storage Temp.	−20°C
UNSPSC	12352202

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