Concanamycin A

SIGMA/C9705 - ≥70% (HPLC)

Synonym: Folimycin

CAS Number: 80890-47-7
Empirical Formula (Hill Notation): C₄₆H₇₅NO₁₄
Molecular Weight: 866.09
MDL Number: MFCD00210037
Linear Formula: C₄₆H₇₅NO₁₄
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-C9705-25UG	25 µg	$213.00 1/EA		Add To Favorites
45-C9705-.1MG	0.1 mg	$691.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

antibiotic activity spectrum	viruses
assay	≥70% (HPLC)
form	solid film
InChI	1S/C46H75NO14/c1-13-16-34-28(7)37(58-38-22-33(48)43(31(10)57-38)60-45(47)53)23-46(54,61-34)30(9)41(51)29(8)42-35(55-11)18-15-17-24(3)19-26(5)39(49)32(14-2)40(50)27(6)20-25(4)21-36(56-12)44(52)59-42/h13,15-18,20-21,26-35,37-43,48-51,54H,14,19,22-23H2,1-12H3,(H2,47,53)/b16-13+,18-15+,24-17+,25-20+,36-21-/t26?,27?,28-,29?,30?,31-,32?,33-,34?,35?,37-,38+,39?,40?,41?,42?,43-,46+/m1/s1
InChI key	DJZCTUVALDDONK-LWLXYWDNSA-N
mode of action	enzyme \| inhibits
Quality Level	200
SMILES string	CCC1C(O)C(C)CC(C)=CC=CC(OC)C(OC(=O)C(OC)=CC(C)=CC(C)C1O)C(C)C(O)C(C)[C@]2(O)C[C@@H](O[C@H]3C[C@@H](O)[C@H](OC(N)=O)[C@@H](C)O3)[C@H](C)C(O2)C=CC
storage temp.	−20°C

Application:	Concanamycin A has been used: • as a lysosomal inhibitor in young and old fibroblasts • as a vacuolar-type H⁺-ATPase inhibitor in presynaptic vesicles • as a lysosomal acidification blocker in HepG2 hepatocytes cells
Biochem/physiol Actions:	Concanamycin A (ConA) inhibits acidification of organelles and perforin-mediated cytotoxicity. It is a vacuolar-type v-ATPase inhibitor. ConA possesses antiprotozoal and antineoplastic properties. It mediates inhibition of the negative factor (Nef) protein of the human immunodeficiency virus.
General description:	Chemical structure: macrolide
General description:	Concanamycin A belongs to the plecomacrolide family and comprises an 18-membered tetraenic macrolide ring.

Symbol	GHS06
Signal word	Danger
Hazard statements	H300 + H310 + H330 - H319
Precautionary statements	P262 - P280 - P301 + P310 + P330 - P302 + P352 + P310 - P304 + P340 + P310 - P305 + P351 + P338
Hazard Codes	T+
Risk Statements	26/27/28-36
Safety Statements	26-36/37/39-45
RIDADR	UN 3462 6.1 / PGII
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥70% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352200

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