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Chlorhexidine digluconate solution

SIGMA/C9394 - 20% in H2O

Synonym: Bis(p-chlorophenyl)diguanidohexane digluconate; 1,6-Bis(N5-[p-chlorophenyl]-N1-biguanido)hexane; 1,1′-Hexamethylenebis(5-[p-chlorophenyl]biguanide)

CAS Number: 18472-51-0
MDL Number: MFCD00083599
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-C9394-25ML 25 mL
 $63.50
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45-C9394-100ML 100 mL
 $167.00
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45-C9394-500ML 500 mL
 $579.00
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antibiotic activity spectrum Gram-negative bacteria
  Gram-positive bacteria
concentration 20% in H2O
density 1.06 g/mL at 25 °C (lit.)
form liquid
InChI 1S/C22H30Cl2N10.2C6H12O7/c23-15-5-9-17(10-6-15)31-21(27)33-19(25)29-13-3-1-2-4-14-30-20(26)34-22(28)32-18-11-7-16(24)8-12-18;2*7-1-2(8)3(9)4(10)5(11)6(12)13/h5-12H,1-4,13-14H2,(H5,25,27,29,31,33)(H5,26,28,30,32,34);2*2-5,7-11H,1H2,(H,12,13)/t;2*2-,3-,4+,5-/m.11/s1
InChI key YZIYKJHYYHPJIB-UUPCJSQJSA-N
mode of action cell membrane | interferes
Quality Level 200 
SMILES string OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.Clc1ccc(NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)Nc2ccc(Cl)cc2)cc1
solubility water: soluble 50 % (w/v)
storage temp. 2-8°C
Application: Chlorhexidine has been used to study how essential oils improve skin antisepsis when combined with chlorhexidine digluconate and is used for skin permeation studies . Chronic rinsing with chlorhexidine has been shown to decrease the saltiness of NaCl and the bitterness of quinine.
Application: Used to study mechanism of membrane dysruption by bis(biguanide) molecules.
Biochem/physiol Actions: Cationic broad-spectrum antimicrobial agent belonging to the bis(biguanide) family. Its mechanism of action involves destabilization of the outer bacterial membrane. It is used primarily as a topical antiseptic/disinfectant in wound healing, at catheterization sites, in various dental applications and in surgical scrubs.
Other Notes: Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Light sensitive.
Density 1.06 g/mL at 25 °C (lit.)
Storage Temp. 2-8°C
UNSPSC 51102829

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