Cordycepin 5′-triphosphate sodium salt

SIGMA/C9137 - ≥95%

Synonym: 3′-dATP; 3′-deoxy-ATP; 3′-Deoxyadenosine 5′-triphosphate

CAS Number: 71997-32-5
Empirical Formula (Hill Notation): C₁₀H₁₆N₅O₁₂P₃
Molecular Weight: 491.18
MDL Number: MFCD00057015
Linear Formula: C₁₀H₁₆N₅O₁₂P₃
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-C9137-1MG	1 mg	$205.00 1/EA		Add To Favorites
45-C9137-5MG	5 mg	$796.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥95%
form	powder
InChI	1S/C10H16N5O12P3.Na.H/c11-8-7-9(13-3-12-8)15(4-14-7)10-6(16)1-5(25-10)2-24-29(20,21)27-30(22,23)26-28(17,18)19;;/h3-6,10,16H,1-2H2,(H,20,21)(H,22,23)(H2,11,12,13)(H2,17,18,19);;
InChI key	FRGBONDYLMUOMH-UHFFFAOYSA-N
mol wt	491.18 g/mol
Quality Level	200
SMILES string	[Na].Nc1ncnc2n(cnc12)C3OC(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)CC3O
storage temp.	−20°C

Application:	Cordycepin 5′-triphosphate sodium salt has been used: • as a transcriptional inhibitor in RNA decay assay • to inhibit polyadenylation in HEK293T cells before harvesting for in- vitro interaction studies through co-immunoprecipitation (co-Ips) • as a positive control in in vitro assays for polymerase inhibition • as a precursor to produce cordycepin monophosphate
Biochem/physiol Actions:	Cordycepin 5′-triphosphate is incorporated into nucleic acid by poly(A) polymerase. Because it lacks a 3′-hydroxyl group chain production it can be used for 3′-end labeling of RNA.
Biochem/physiol Actions:	Cordycepin exhibits various metabolic effects by activating AMP-activated protein kinase (AMPK) in humans. Cordycepin triphosphate inhibits picornavirus polymerase-specific RNA synthesis by blocking in vitro [3H]GMP incorporation. It also retards cell growth by inhibiting RNA synthesis.
General description:	Cordycepin (3′-deoxyadenosine) is a cytotoxic adenosine analog and a bioactive agent extracted from Cordyceps militaris. Cordycepin 5′-triphosphate is a toxic derivative of cordycepin.
Packaging:	1, 5 mg in glass bottle

Symbol	GHS07,GHS08
Signal word	Warning
Hazard statements	H302 + H332 - H315 - H319 - H335 - H351
Precautionary statements	P201 - P301 + P312 - P302 + P352 - P304 + P340 + P312 - P305 + P351 + P338 - P308 + P313
Hazard Codes	Xn
Risk Statements	20/22-36/37/38-40
Safety Statements	22-26-36-45
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥95%
Storage Temp.	−20°C
UNSPSC	41106305

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