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CEP-701 hydrate

SIGMA/C7869 - ≥98% (HPLC)

Synonym: KT-5555 hydrate; Lestaurtinib hydrate

CAS Number: 111358-88-4 (anhydrous)
Empirical Formula (Hill Notation): C26H21N3O4 · xH2O
Molecular Weight: 439.46 (anhydrous basis)
MDL Number: MFCD12828858
Linear Formula: C26H21N3O4 · xH2O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-C7869-1MG 1 mg
 $205.00
1/EA		 Add To Favorites
45-C7869-5MG 5 mg
 $801.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white
form powder
InChI 1S/C26H21N3O4.H2O/c1-25-26(32,12-30)10-18(33-25)28-16-8-4-2-6-13(16)20-21-15(11-27-24(21)31)19-14-7-3-5-9-17(14)29(25)23(19)22(20)28;/h2-9,18,30,32H,10-12H2,1H3,(H,27,31);1H2/t18-,25+,26+;/m1./s1
InChI key LPOQWFBZBJTLEO-GMEYHWBASA-N
Quality Level 100 
SMILES string O.C[C@]12O[C@H](C[C@]1(O)CO)n3c4ccccc4c5c6C(=O)NCc6c7c8ccccc8n2c7c35
solubility DMSO: >10 mg/mL
storage temp. −20°C
Application: CEP-701 hydrate has been used as a tyrosine kinase inhibitor:
• to study its effects on early growth response protein (EGR) genes and nerve growth factor (NGF) stimulation in human epithelial cells
• as a supplement in reservoir solution for co-crystallization studies with human receptor-interacting protein kinase 4 (RIPK4)
• as an FMS-like tyrosine kinase 3 (FLT3) inhibitor-gold nanoparticle conjugate to study its effects on acute myeloid leukemia
Biochem/physiol Actions: CEP-701 hydrate, also known as Lestaurtinib, can repress Janus kinase 2/signal transducer and activator of transcription 5 (JAK2/STAT5) signaling by the specific inhibition of JAK2.
Biochem/physiol Actions: CEP-701 is a Flt-3 receptor tyrosine kinase inhibitor.
Features and Benefits: This compound is a featured product for Kinase Phosphatase Biology research. Click here  to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Packaging: 1, 5 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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