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Canrenoic acid potassium salt

SIGMA/C7287 - powder

Synonym: 17-Hydroxy-3-oxopregna-4,6-diene-21-carboxylic acid; Potassium canrenoate

CAS Number: 2181-04-6
Empirical Formula (Hill Notation): C22H30KO4
Molecular Weight: 397.57
EC Number: 218-554-9
MDL Number: MFCD05662375
Linear Formula: C22H30O4K
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-C7287-5G 5 g
 $242.00
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This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: C7287-5G

 

color light yellow to tan
form powder
InChI 1S/C22H30O4.K.H/c1-20-9-5-15(23)13-14(20)3-4-16-17(20)6-10-21(2)18(16)7-11-22(21,26)12-8-19(24)25;;/h3-4,13,16-18,26H,5-12H2,1-2H3,(H,24,25);;/t16-,17+,18+,20+,21+,22-;;/m1../s1
InChI key YLXFIHIYNGPPSF-HUHWECDNSA-N
Quality Level 100 
SMILES string [K].[H][C@]12CC[C@@]3(C)[C@@]([H])(CC[C@@]3(O)CCC(O)=O)[C@]1([H])C=CC4=CC(=O)CC[C@]24C
Analysis Note: Aqueous solutions may contain some insoluble material.
Application: Canrenoic acid potassium salt has been used as a human uridine 5′-diphospho (UDP)-glucuronosyltransferase inhibitor to study its effects on trifluoperazine (TFP) substrate selectivity. It has also been used to study its effects on the formation of aldosterone 18-glucuronide (ALDO 18β-G) in recombinant UDP-Glucuronosyltransferase-2B7 (UGT2B7), human liver (HLM) and human kidney cortical (HKCM) microsomes.
Biochem/physiol Actions: Competitive aldosterone receptor antagonist.
Biochem/physiol Actions: Competitive aldosterone receptor antagonist. Potassium canrenoate reduces the effects of aldosterone-induced increases in blood pressure and in cardiovascular fibrosis in animals with high sodium intake. It is used clinically for its anti-fibrotic effects. At higher doses it is genotoxic to liver and increases tumor incidence in rodent models.
Packaging: 5 g in poly bottle
Symbol GHS07  GHS07
Signal word Warning
Hazard statements H302
Hazard Codes Xn
Risk Statements 22
Safety Statements 36
RIDADR NONH for all modes of transport
WGK Germany WGK 3
UNSPSC 12352106

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