Cytochalasin B from Drechslera dematioidea

SIGMA/C6762 - ≥98% (HPLC), powder

Synonym: Phomin

CAS Number: 14930-96-2
Empirical Formula (Hill Notation): C₂₉H₃₇NO₅
Molecular Weight: 479.61
EC Number: 239-000-2
MDL Number: MFCD00077704
Linear Formula: C₂₉H₃₇NO₅
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-C6762-1MG	1 mg	$102.00 1/EA		Add To Favorites
45-C6762-5MG	5 mg	$424.00 1/EA		Add To Favorites
45-C6762-10MG	10 mg	$612.00 1/EA		Add To Favorites
45-C6762-25MG	25 mg	$1210.00 1/EA		Add To Favorites
45-C6762-50MG	50 mg	$2100.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

antibiotic activity spectrum	fungi
assay	≥98% (HPLC)
color	white
form	powder
InChI	1S/C29H37NO5/c1-18-9-7-13-22(31)15-16-25(32)35-29-23(14-8-10-18)27(33)20(3)19(2)26(29)24(30-28(29)34)17-21-11-5-4-6-12-21/h4-6,8,11-12,14-16,18-19,22-24,26-27,31,33H,3,7,9-10,13,17H2,1-2H3,(H,30,34)/b14-8+,16-15+/t18-,19-,22-,23+,24+,26+,27-,29-/m1/s1
InChI key	GBOGMAARMMDZGR-TYHYBEHESA-N
mode of action	DNA synthesis \| interferes
Quality Level	300
SMILES string	C[C@@H]1CCC[C@@H](O)C=CC(=O)O[C@]23[C@@H](C=CC1)[C@H](O)C(=C)[C@@H](C)[C@H]2[C@H](Cc4ccccc4)NC3=O
solubility	DMSO: 10 mg/mL
storage temp.	−20°C

Biochem/physiol Actions:	Cell permeable fungal toxin that disrupts contractile microfilaments by inhibiting actin polymerization. This, in turn, induces DNA fragmentation, inhibits cell division, and disrupts many cell processes. Inhibits glucose transport.
Biochem/physiol Actions:	One of a group of fungal metabolites that interfere with a wide variety of cellular movements. Useful tool for characterizing some of the polymerization properties of actin, and in studies on cytokinesis. Probe for the two hexose-transport systems in rat L6 myoblasts.
General description:	Cytochalasin B is a cell-permeable fungal toxin / mycotoxin that binds to the ′barbed′ end of actin / actin filaments. This binding leads to: • Disruption of actin filaments and of interaction of actin filaments in solution • Inhibition of actin polymerization • Inhibition of subunit association and dissociation Cytochalasin B is widely used in studies of glucose transporters (GLUT). Cytochalasin B is also used as an integral part of various in vitro micronucleus assay protocols.
Packaging:	1, 5, 10, 25, 50 mg in serum bottle

Symbol	GHS06,GHS08
Signal word	Danger
Hazard statements	H300 + H310 + H330 - H361
Precautionary statements	P201 - P202 - P260 - P280 - P302 + P352 + P310 - P304 + P340 + P310
Hazard Codes	T+
Risk Statements	63-26/27/28
Safety Statements	28-36/37-45
RIDADR	UN 1544PSN1 6.1 / PGI
WGK Germany	WGK 3

Purity	≥98% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352202

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