(−)-Cotinine
SIGMA/C5923 - ≥98%
Synonym: (S)
CAS Number: 486-56-6
Empirical Formula (Hill Notation): C10H12N2O
Molecular Weight: 176.22
EC Number: 207-634-9
MDL Number: MFCD00077696
Linear Formula: C10H12N2O
Product Type: Chemical
ATR-IR Spectra for (S)-1-Methyl-5-(3-pyridyl)-2-pyrrolidinone.
FT-NMR Spectra for (S)-1-Methyl-5-(3-pyridyl)-2-pyrrolidinone.
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: C5923-1G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: C5923-250MG
| assay | ≥98% |
| bp | 250 °C/150 mmHg (lit.) |
| form | crystals |
| InChI | 1S/C10H12N2O/c1-12-9(4-5- |
| InChI key | UIKROCXWUNQSPJ-VIFPVBQESA |
| mp | 40-42 °C (lit.) |
| Quality Level | 200  |
| SMILES string | CN1[C@@H](CCC1=O)c2cccnc2 |
| storage temp. | 2-8°C |
| Application: | Cotinine has been used: • for oxygen-glucose deprivation (OGD) studies to model ischemic stroke • as a standard to determine serum cotinine measurements using liquid chromatography with tandem mass spectrometry (LC-MS/MS) • to evaluate the adverse developmental potential of cotinine • to assess cognitive behavior in mice |
| Biochem/physiol Actions: | Major metabolite of nicotine in humans. |
| General description: | Cotinine is an alkaloid extracted from tobacco leaves. It can cross the blood-brain barrier. Cotinine is used to treat Alzheimer′s disease (AD), schizophrenia and post-traumatic stress disorder (PTSD). |
| Packaging: | 1 g in glass bottle |
| Packaging: | 250 mg in glass bottle |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 - H315 - H319 - H335 |
| Precautionary statements | P301 + P312 + P330 - P302 + P352 - P305 + P351 + P338 |
| Hazard Codes | Xn |
| Risk Statements | 22-36/37/38 |
| Safety Statements | 26-36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | 230.0 °F - closed cup |
| Flash Point(C) | 110 °C - closed cup |
| Purity | ≥98% |
| bp | 250 °C/150 mmHg (lit.) |
| mp | 40-42 °C (lit.) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |