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CA-074 methyl ester

SIGMA/C5857 - ≥99% (TLC)

Synonym: (L-3-trans-(Propylcarbamyl)oxirane-2-carbonyl)-L-isoleucyl-L-proline methyl ester

CAS Number: 147859-80-1
Empirical Formula (Hill Notation): C19H31N3O6
Molecular Weight: 397.47
MDL Number: MFCD03452890
Linear Formula: C19H31N3O6
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-C5857-5MG 5 mg
 $485.00
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assay ≥99% (TLC)
biological source synthetic (organic)
form solid
InChI 1S/C19H31N3O6/c1-5-9-20-16(23)14-15(28-14)17(24)21-13(11(3)6-2)18(25)22-10-7-8-12(22)19(26)27-4/h11-15H,5-10H2,1-4H3,(H,20,23)(H,21,24)/t11?,12-,13-,14-,15-/m0/s1
InChI key XGWSRLSPWIEMLQ-RQLZCWDZSA-N
Quality Level 100 
SMILES string CCCNC(=O)[C@H]1O[C@@H]1C(=O)N[C@@H](C(C)CC)C(=O)N2CCC[C@H]2C(=O)OC
storage temp. −20°C
Application: CA-074 methyl ester has been used as cathepsin B inhibitor in cardiomyocytes, HeLa cells and human pancreatic cancer PANC-1 cells.
Biochem/physiol Actions: CA-074 methyl ester is a cell-permeable analog of CA-074. It is an inhibitor of cathepsin B especially the intracellular type. and undergoes intracellular transition into active CA-074 by the action of esterases. CA-074 methyl ester also inhibits cathepsin L.
Features and Benefits: This compound is a featured product for Apoptosis research. Click here  to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥99% (TLC)
Storage Temp. −20°C
UNSPSC 12352108

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