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Ceftriaxone disodium salt hemi(heptahydrate)

SIGMA/C5793 - third-generation cephalosporin antibiotic

Synonym: Ceftriaxone disodium hemiheptahydrate

CAS Number: 104376-79-6
Empirical Formula (Hill Notation): C18H16N8Na2O7S3 · 3.5H2O
Molecular Weight: 661.60
EC Number: 277-930-0
MDL Number: MFCD01750405
Linear Formula: C18H16N8Na2O7S3 · 3.5H2O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-C5793-250MG 250 mg
 $126.00
1/EA		 Add To Favorites
45-C5793-1G 1 g
 $384.00
1/EA		 Add To Favorites

 

antibiotic activity spectrum Gram-negative bacteria
  Gram-positive bacteria
form powder or crystals
InChI 1S/2C18H18N8O7S3.4Na.7H2O/c2*1-25-18(22-12(28)13(29)23-25)36-4-6-3-34-15-9(14(30)26(15)10(6)16(31)32)21-11(27)8(24-33-2)7-5-35-17(19)20-7;;;;;;;;;;;/h2*5,9,15H,3-4H2,1-2H3,(H5,19,20,21,23,27,29,31,32);;;;;7*1H2/q;;4*+1;;;;;;;/p-4/b2*24-8-;;;;;;;;;;;/t2*9-,15-;;;;;;;;;;;/m11.........../s1
InChI key PMRZKYOXTPBIQF-MAODNAKNSA-J
mode of action cell wall synthesis | interferes
Quality Level 200 
SMILES string O.O.O.O.O.O.O.[Na+].[Na+].CON=C(/C(=O)N[C@H]1C2SCC(CSC3=NC(=O)C(=O)N([Na])N3C)=C(N2C1=O)C([O-])=O)c4csc(N)n4.CON=C(/C(=O)N[C@H]5C6SCC(CSC7=NC(=O)C(=O)N([Na])N7C)=C(N6C5=O)C([O-])=O)c8csc(N)n8
storage temp. 2-8°C
Application: Ceftriaxone was used to study drug-induced immune hemolytic anemias, prophylactic strategies to reduce neonatal encephalopathy, pentylenetetrazole-evoked convulsions, the effect of expression, binding, and inhibition of PDP1 and other penicillin-binding proteins (PBPs) on bacterial cell wall mucopeptide synthesis.
Biochem/physiol Actions: Ceftriaxone is a third-generation cephalosporin antibiotic that disrupts the synthesis of the peptidoglycan layer of bacterial cell walls. It is effective against Gram-positive and Gram-negative bacteria. Ceftriaxone is thought to increase EAAT2 pump expression in the central nervous system and to reduce glutamatergic toxicity.
General description: Chemical structure: ß-lactam
Other Notes: Keep container tightly closed in a dry and well-ventilated place.
Storage Temp. 2-8°C
UNSPSC 51284150

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