CA-074

SIGMA/C5732 - ≥98% (HPLC)

Synonym: (L-3-trans-(Propylcarbamyl)oxirane-2-carbonyl)-L-isoleucyl-L-proline

CAS Number: 134448-10-5
Empirical Formula (Hill Notation): C₁₈H₂₉N₃O₆
Molecular Weight: 383.44
MDL Number: MFCD00797531
Linear Formula: C₁₈H₂₉N₃O₆
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-C5732-5MG	5 mg	$554.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
biological source	synthetic (organic)
form	powder
InChI	1S/C18H29N3O6/c1-4-8-19-15(22)13-14(27-13)16(23)20-12(10(3)5-2)17(24)21-9-6-7-11(21)18(25)26/h10-14H,4-9H2,1-3H3,(H,19,22)(H,20,23)(H,25,26)/t10?,11-,12-,13-,14-/m0/s1
InChI key	ZEZGJKSEBRELAS-NSIINPIOSA-N
Quality Level	200
SMILES string	CCCNC(=O)[C@H]1O[C@@H]1C(=O)N[C@@H]([C@H](C)CC)C(=O)N2CCC[C@H]2C(O)=O
solubility	methanol: 1 mg/mL, clear, colorless
storage temp.	−20°C

Application:	CA-074 has been used as a cathepsin B inhibitor: • to study its effect on pseudotyped viruses bearing S proteins harboring R642M and N714K using HeLa cells • to determine the role of autophagy in glucose deprivation (GD)-induced damage • to study its effects on neuronal function upon exposure to His-cathepsin B (CATB)
Biochem/physiol Actions:	CA-074 is a potent and a selective inhibitor of cathepsin B. It is useful to study the biological function of cathepsin B in vivo. Studies show that CA-074 can also inhibit cathepsin L under reducing conditions.

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352200

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