Anti-Cytochrome c antibody produced in sheep
SIGMA/C5723 - whole antiserum
MDL Number: MFCD01864291
Product Type: Chemical
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| antibody form | whole antiserum |
| antibody product type | primary antibodies |
| biological source | sheep |
| clone | polyclonal |
| conjugate | unconjugated |
| mol wt | antigen 14.4 kDa |
| Quality Level | 200  |
| shipped in | dry ice |
| species reactivity | human, rabbit, canine, rat |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunoprecipitation (IP): suitable |
| indirect immunofluorescence: suitable | |
| western blot: 1:5,000 using MCF-7, Rat-1, MDCK or Jurkat cell extracts | |
| UniProt accession no. | P99999  |
| Application: | Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below. Western Blotting (1 paper) |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | Cytochrome c is an electron transport protein released from mitochondria as an early committed event in apoptosis. Cytochrome c and dATP are cofactors for the mammalian apoptosome, which is composed of Apaf-1, Bcl-2, and procaspase 9. When caspase 9 is activated, activation of other caspases follow including the death protease caspase 3. The release of cytochrome c is inhibited by the presence of Bcl-2 on these organelles preventing the initiation of apoptosis. In cells induced by several apoptotic agents (such as UV irradiation, staurosporine, and overexpression of Bax), caspase inhibitors do not prevent cytochrome c release. |
| Immunogen: | rabbit cytochrome c |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |