Cryptotanshinone
SIGMA/C5624 - ≥98% (HPLC)
Synonym: 1,2,6,7,8,9-
CAS Number: 35825-57-1
Empirical Formula (Hill Notation): C19H20O3
Molecular Weight: 296.36
MDL Number: MFCD07636810
Linear Formula: C19H20O3
Product Type: Chemical
| application(s) | metabolomics vitamins, nutraceuticals, and natural products |
| assay | ≥98% (HPLC) |
| color | orange-brown |
| form | powder |
| InChI | 1S/C19H20O3/c1-10-9-22-18 |
| InChI key | GVKKJJOMQCNPGB-JTQLQIEISA |
| optical activity | [α]/D -80 to -99°, c = 0.5 in chloroform-d |
| Quality Level | 100  |
| SMILES string | C[C@H]1COC2=C1C(=O)C(=O)c |
| solubility | DMSO: ≥5 mg/mL |
| storage condition | desiccated |
| protect from light | |
| storage temp. | 2-8°C |
| Biochem/physiol Actions: | Cryptotanshinone is a quinoid diterpene isolated from the root of the Asian medicinal plant, Salvia miotiorrhiza bunge. Recently it was discovered that the compound is a potent STAT3 inhibitor. Cryptotanshinone rapidly inhibited STAT3 Tyr705 phosphorylation through a JAK2-independent mechanism. Cryptotanshinone selectively inhibits STAT3-activated cell lines through binding to monomer STAT3, subsequently blocking the dimerization and inhibiting STAT3 transcriptional regulatory activity. Previously, it was reported that the compound counteracts inflammation through the inhibition of cyclooxygenase II activity and endothelin-1 expression. In traditional oriental medicine dried roots of Salvia Miltiorrhiza Bunge (Danshen) have commonly been used for the treatment of circulatory disorders, liver disease, coronary heart disease, hepatitis, and chronic renal failure. |
| Biochem/physiol Actions: | Cryptotanshinone is a specific STAT3 inhibitor. It prevents STAT3 dimerization. |
| Packaging: | 5, 25 mg in glass bottle |
| Hazard Codes | T,N |
| Risk Statements | 25-50/53 |
| Safety Statements | 45-60-61 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |