CyPPA

SIGMA/C5493 - ≥98% (HPLC), solid

Synonym: Cyclohexyl-[2-(3,5-dimethyl-pyrazol-1-yl)-6-methyl-pyrimidin-4-yl]-amine

CAS Number: 73029-73-9
Empirical Formula (Hill Notation): C₁₆H₂₃N₅
Molecular Weight: 285.39
MDL Number: MFCD01550586
Linear Formula: C₁₆H₂₃N₅
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-C5493-5MG	5 mg	$164.00 1/EA		Add To Favorites
45-C5493-25MG	25 mg	$728.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white
form	solid
InChI	1S/C16H23N5/c1-11-10-15(18-14-7-5-4-6-8-14)19-16(17-11)21-13(3)9-12(2)20-21/h9-10,14H,4-8H2,1-3H3,(H,17,18,19)
InChI key	USEMRPYUFJNFQN-UHFFFAOYSA-N
Quality Level	100
SMILES string	Cc1cc(NC2CCCCC2)nc(n1)-n3nc(C)cc3C
solubility	DMSO: >10 mg/mL
	H₂O: <2 mg/mL
storage temp.	2-8°C

Application:	CyPPA has been used: • to test its inhibitory functionality on melanogenesis • as an activator of small conductance potassium channel-3 (SK3) in mesenteric artery segments • in the activation of calcium-activated potassium (SK) channels in murine hippocampal neurons HT-22 cells
Biochem/physiol Actions:	CyPPA is a positive modulator of small conductance Ca²⁺-activated K⁺ channels; selective for SK3 and SK2.
Biochem/physiol Actions:	CyPPA is a positive modulator of small conductance Ca²⁺-activated K⁺ channels; selective for SK3 and SK2. CyPPA is a first subtype selective SK channel positive modulator with an EC₅₀ of 5.6 μM and 14 μM, efficacy 90% and 71% for hSK3 and hSK2, respectively. CyPPA is a tool for distinguishing SK2 and SK3 from SK1 and IK; no other agents distinguish these channels.
Features and Benefits:	This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging:	5, 25 mg in glass bottle

Symbol	GHS07
Signal word	Warning
Hazard statements	H315 - H319 - H335 - H413
Precautionary statements	P273 - P302 + P352 - P305 + P351 + P338
Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36/37
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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