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Cycloheximide solution

SIGMA/C4859 - Ready-Made Solution, microbial, 100 mg/mL in DMSO, Suitable for cell culture

Synonym: CHX

CAS Number: 66-81-9
Empirical Formula (Hill Notation): C15H23NO4
Molecular Weight: 281.35
MDL Number: MFCD00082346
Linear Formula: C15H23NO4
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-C4859-1ML 1 mL
 $138.00
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antibiotic activity spectrum fungi
  yeast
biological source microbial
concentration 100 mg/mL in DMSO
description suitable for testing specifications (CHO C. growth inhibitor)
form ready-to-use solution
InChI 1S/C15H23NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19)7-10/h8-12,17H,3-7H2,1-2H3,(H,16,18,19)/t8-,9-,11-,12+/m0/s1
InChI key YPHMISFOHDHNIV-FSZOTQKASA-N
mode of action protein synthesis | interferes
Quality Level 300 
SMILES string O=C1[C@@]([C@H](O)CC2CC(NC(C2)=O)=O)([H])C[C@@H](C)C[C@@H]1C
solubility DMSO: soluble
storage temp. 2-8°C
Biochem/physiol Actions: Cycloheximide (CHX) is an antibiotic produced by S. griseus. Its main biological activity is translation inhibition in eukaryotes resulting in cell growth arrest and cell death. CHX is widely used for selection of CHX-resistant strains of yeast and fungi, controlled inhibition of protein synthesis for detection of short-lived proteins and super-induction of protein expression, and apoptosis induction or facilitation of apoptosis induction by death receptors.
Biochem/physiol Actions: Tested for cell growth arrest, selection of cycloheximide resistant yeast, apoptosis induction, and facilitation of apoptosis induction by FasL.
Other Notes: Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.Hygroscopic. Storage class (TRGS 510): Non-combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials.
Packaging: 1 mL in glass bottle
Storage Temp. 2-8°C
UNSPSC 12352111

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