BID, Caspase-8-cleaved from mouse
SIGMA/C4733 - ≥95% (SDS-PAGE), recombinant, expressed in E. coli, buffered aqueous solution
MDL Number: MFCD03456214
Product Type: Chemical
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| assay | ≥95% (SDS-PAGE) |
| form | buffered aqueous solution |
| Quality Level | 200  |
| recombinant | expressed in E. coli |
| shipped in | dry ice |
| storage temp. | −20°C |
| UniProt accession no. | P70444  |
| Analysis Note: | Measured by its ability to induce cytochrome c release from isolated mouse liver mitochondria. |
| Biochem/physiol Actions: | Caspase-8-cleaved BID relocates from the cytosol to the outer mitochondrial membrane where its interaction with Bak alters mitochondrial membrane permeability. |
| General description: | Mouse BID cleaved with caspase-8 generates the amino-terminal fragment (amino acids 1-59, 7 kDa) and the carboxy-terminal fragment (amino acids 60-195, 15 kDa). On size exclusion chromatography cleaved BID elutes at 27 kDa indicating that the fragments remain associated. |
| Physical form: | 0.2 μm filtered solution in 25 mM HEPES, pH 7.5, and 0.1 M KCl. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | nwg |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥95% (SDS-PAGE) |
| Storage Temp. | −20°C |
| UNSPSC | 12352202 |