Synonym: 2,16α,20,25-Tetrahydroxy-9-methyl-19-Nor-9β,10α-lanosta-1,5,23-triene-3,11,22-trione; Elatericin B; JSI-124; NSC 521777
CAS Number: 2222-07-3 (anhydrous)
Empirical Formula (Hill Notation): C30H42O7 · xH2O
Molecular Weight: 514.65 (anhydrous basis)
EC Number: 218-736-8
MDL Number: MFCD09971044
Linear Formula: C30H42O7 · xH2O
Product Type: Chemical
| assay |
≥95% (HPLC) |
| color |
white to off-white |
| form |
solid |
| InChI |
1S/C30H42O7.H2O/c1-25(2,36)12-11-21(33)30(8,37)23-19(32)14-27(5)20-10-9-16-17(13-18(31)24(35)26(16,3)4)29(20,7)22(34)15-28(23,27)6;/h9,11-13,17,19-20,23,31-32,36-37H,10,14-15H2,1-8H3;1H2/b12-11+;/t17-,19-,20+,23+,27+,28-,29+,30+;/m1./s1 |
| InChI key |
ZKDSPEWKSJCXQE-NEBRQAMTSA-N |
| Quality Level |
100  |
| SMILES string |
O.CC(C)(O)C=CC(=O)[C@](C)(O)[C@H]1[C@H](O)C[C@@]2(C)[C@@H]3CC=C4[C@@H](C=C(O)C(=O)C4(C)C)[C@]3(C)C(=O)C[C@]12C |
| solubility |
DMSO: >5 mg/mL |
| storage temp. |
−20°C |
| Biochem/physiol Actions: |
Cucurbitacin I (JSI-124) is a novel selective inhibitor of the janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) signaling pathway with anti-proliferative and anti-tumor properties. |
| Biochem/physiol Actions: |
Cucurbitacin I is a novel selective JAK/STAT3 inhibitor. |
| Features and Benefits: |
This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm . |
| Features and Benefits: |
This compound is featured on the JAKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| Packaging: |
1 mg in glass bottle |
| Symbol |
 GHS06 |
| Signal word |
Danger |
| Hazard statements |
H300 |
| Precautionary statements |
P264 - P301 + P310 |
| Hazard Codes |
T+ |
| Risk Statements |
28 |
| Safety Statements |
28-36/37-45 |
| RIDADR |
UN 2811 6.1 / PGI |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥95% (HPLC) |
| Storage Temp. |
−20°C |
| UNSPSC |
12352200 |
