CD152/Fc Chimera, Cytolytic from mouse
SIGMA/C4483 - recombinant, expressed in NS.1 cells, buffered aqueous solution
Synonym: CTLA4/Fc Chimera, cytolytic
MDL Number: MFCD01092888
Product Type: Chemical
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| assay | ≥99% (SDS-PAGE) |
| biological source | mouse |
| form | buffered aqueous solution |
| impurities | ≤1 EU/mg protein Endotoxin level (LAL test) |
| mol wt | 97 kDa |
| packaging | pkg of 1 mg |
| Quality Level | 200  |
| recombinant | expressed in NS.1 cells |
| shipped in | wet ice |
| storage condition | avoid repeated freeze/thaw cycles |
| storage temp. | −20°C |
| UniProt accession no. | P09793  |
| Biochem/physiol Actions: | CD152 (CTLA4), a cell surface glycoprotein expressed at low levels on activated T cells, is a high affinity receptor for the costimulatory molecules CD80 (B7-1) and CD86 (B7-2). A related cell surface glycoprotein, CD28, binds to CD80 and CD86 with lower affinity. The soluble CD152/Fc chimeric fusion protein blocks the B7/CD28 signaling pathway by binding to CD80 and CD86. |
| General description: | The complement (C1q) and FcγR I binding sites of the Fcγ2a fragment allow the Fc portion of the fusion protein to effectively facilitate direct antibody directed cytotoxicity (ADCC) and complement directed cytotoxicity (CDC). |
| Other Notes: | The extracellular domain (160 amino acids) of mouse CD152 is fused to mouse IgG2a Fc domain. |
| Physical form: | Solution, 0.2 μm filtered, in phosphate buffered saline, pH 7.4, with no preservative added. |
| Preparation Note: | Purified from serum-free tissue culture supernatant |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥99% (SDS-PAGE) |
| Storage Temp. | −20°C |
| UNSPSC | 51111800 |