Cathepsin G from human leukocytes
SIGMA/C4428 - lyophilized powder, ≥60 units/mg protein (Bradford)
CAS Number: 107200-92-0
MDL Number: MFCD00130750
Product Type: Chemical
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| biological source | human leucocytes |
| form | lyophilized powder |
| mol wt | 23-30 kDa |
| Quality Level | 200  |
| shipped in | dry ice |
| specific activity | ≥60 units/mg protein (Bradford) |
| storage temp. | −20°C |
| UniProt accession no. | P08311  |
| Application: | Cathepsin G from human leukocytes has been used to determine protease sensitivity. It has also been used for the stimulation and staining of dendritic cells and macrophage. |
| Biochem/physiol Actions: | Cathepsin G from human leukocytes degrades various proteins, such as elastin, collagen, fibrinogen and immunoglobin. It may be implicated in muscle catabolism. Cathepsin G is involved in the activation or inactivation of protein hormones and the inactivation of plasma proteinase inhibitors. It alters the cytoskeleton, enhances the permeability of vascular endothelial cells and the chemotaxis of inflammatory cells. Cathepsin G is associated with autoimmunity and cancer. It exhibits chymotrypsin and trypsin like activity. Cathepsin G modulates neutrophil effector functions. |
| Biochem/physiol Actions: | Cathepsin G has pro-apoptotic activity and can activate caspases in vitro. |
| General description: | Cathepsin G from human leukocytes is a neutral proteinase secreted by neutrophil granulocytes. It belongs to the family of serine proteases. Cathepsin G is a glycoprotein, which contains 1% carbohydrate. The gene is located on human chromosome 14q12. |
| Other Notes: | One unit will release one nanomole of p-nitroaniline per second from N-succinyl-Ala-Ala-Pro-Ph |
| Physical form: | Lyophilized from 0.5 M pyridinium acetate, pH 5.3. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| activity | specific activity: ≥60 units/mg protein (Bradford) |
| Storage Temp. | −20°C |
| Enzyme Commission (EC) Number | 3.4.21.20 ( BRENDA | IUBMB ) |
| UNSPSC | 12352200 |