Chlorzoxazone
SIGMA/C4397
Synonym: 5-
CAS Number: 95-25-0
Empirical Formula (Hill Notation): C7H4ClNO2
Molecular Weight: 169.57
EC Number: 202-403-9
MDL Number: MFCD00005717
Linear Formula: C7H4ClNO2
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: C4397-100G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: C4397-25G
| assay | ≥98% (TLC) |
| color | white to off-white |
| form | powder |
| InChI | 1S/C7H4ClNO2/c8-4-1-2-6-5 |
| InChI key | TZFWDZFKRBELIQ-UHFFFAOYSA |
| mp | 191-192 °C (lit.) |
| originator | Johnson & Johnson |
| Quality Level | 100  |
| SMILES string | Clc1ccc2OC(=O)Nc2c1 |
| solubility | DMSO: 50 mg/mL, clear |
| storage temp. | room temp |
| Application: | Chlorzoxazone may be used: • as a calcium-activated potassium (KCa) channel activator in patch-clamp electrophysiology to test its effect on dendritic hyperexcitability • as a substrate for cytochrome P450 2E1 (CYP2E1) enzyme in cultured human hepatocytes • as a benzimidazolone compound to test its effect on epithelial sodium (Na+) transport |
| Biochem/physiol Actions: | Chlorzoxazone inhibits the multisynaptic reflex arcs primarily in the spinal cord and brain subcortical areas. It is an activator of calcium activated potassium channels and may contribute to the aortic artery relaxation in mice. Chlorzoxazone also activates the calcium-activated potassium (KCa) channel and small conductance calcium-activated potassium channels (SK). It is metabolized by cytochrome P450 2E1 (CYP2E1) and serves as a probe for monitoring this enzyme function. |
| Biochem/physiol Actions: | Chlorzoxazone is a skeletal muscle relaxant. |
| Features and Benefits: | This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm . |
| Features and Benefits: | This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| Features and Benefits: | This compound was developed by Johnson & Johnson . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here . |
| Packaging: | 25, 100 g in poly bottle |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 - H315 - H319 - H335 |
| Precautionary statements | P301 + P312 + P330 - P302 + P352 - P305 + P351 + P338 |
| Hazard Codes | Xn |
| Risk Statements | 22-36/37/38 |
| Safety Statements | 26-36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (TLC) |
| mp | 191-192 °C (lit.) |
| Storage Temp. | room temp |
| UNSPSC | 12352200 |