Coenzyme A hydrate

SIGMA/C4282 - ≥85% (UV, HPLC)

Synonym: CoA

CAS Number: 85-61-0 (anhydrous)
Empirical Formula (Hill Notation): C₂₁H₃₆N₇O₁₆P₃S · xH₂O
Molecular Weight: 767.53 (anhydrous basis)
MDL Number: MFCD06795839
Linear Formula: C₂₁H₃₆N₇O₁₆P₃S · xH₂O
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-C4282-10MG	10 mg	$83.80 1/EA	Add To Favorites
45-C4282-25MG	25 mg	$139.00 1/EA	Add To Favorites
45-C4282-100MG	100 mg	$410.00 1/EA	Add To Favorites

Coenzyme A (CoA, CoASH or HSCoA) is the key cofactor in first step of the TCA cycle, responsible for transferring the acetyl group from pyruvate oxidation to oxaloacetate yielding citrate. Coenzyme A is also a critical cofactor in fatty acid metabolism. Coenzyme A carries fatty acids through the catabolic/oxidation process in the mitochondria and transfers acetyl groups during the elongation process of fatty acid synthesis in the cytosol.

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This image depicts SKU: C4282-100MG

Properties
Descriptions
Safety Info.
Basic Data

assay	≥85% (UV, HPLC)
biological source	yeast
form	powder
functional group	phospholipid
InChI	1S/C21H36N7O16P3S.H2O/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28;/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35);1H2/t11-,14-,15-,16+,20-;/m1./s1
InChI key	TVSAELAFGDOPKI-BLPRJPCASA-N
Quality Level	200
shipped in	dry ice
SMILES string	O.CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)n2cnc3c(N)ncnc23)[C@@H](O)C(=O)NCCC(=O)NCCS
storage temp.	−70°C

Application:	Coenzyme A hydrate has been used in the thiolase enzyme assay of recombinant acetoacetyl-CoA thiolase (rACAT) in Clonorchis sinensis. It may be used as a reference standard in Raman spectra measurements.
Biochem/physiol Actions:	Coenzyme A (CoA) is an essential metabolic cofactor synthesized from cysteine, pantothenate, and ATP.
Biochem/physiol Actions:	Coenzyme A (CoA) is an essential metabolic cofactor synthesized from cysteine, pantothenate, and ATP. CoA plays important roles in many metabolic pathways, including the tricarboxylic acid cycle, and the synthesis and oxidation of fatty acids. One of the main functions of CoA is the carrying and transfer of acyl groups. Acylated deriviates, for example acetyl-CoA, are critical intermediates in many metabolic reactions. CoA levels can be altered during starvation, and in conditions such as cancer, diabetes, and alcoholism.
Disclaimer:	The free acid is less stable than the sodium or lithium salt; 5% decomposition may occur within 6 months when stored at −80 °C.
Packaging:	10 mg in glass bottle
Packaging:	25, 100 mg in poly bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥85% (UV, HPLC)
Storage Temp.	−70°C
UNSPSC	12352100

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